Table 5. Correlation between BRAF and KRAS mutations and demographic and histological parameters.
| KRAS MUTATION | BRAF V600E MUTATION | |||||
|---|---|---|---|---|---|---|
| Negative | Positive | P-value | Negative | Positive | P-value | |
| N (%) | N (%) | N (%) | N (%) | |||
| Age | ||||||
| <55 (N = 74) | 66 (89.2) | 8 (10.8) | 0.385 | 38 (51.4) | 36 (48.6) | 0.014 |
| >55 (N = 16) | 13 (81.3) | 3(18.8) | 11(68.8) | 5 (31.3) | ||
| Gender | ||||||
| Male (N = 27) | 24(88.9) | 3(11.1) | 0.835 | 13(48.1) | 14(51.9) | 0.493 |
| Female (N = 63) | 55(87.3) | 8(12.7) | 36 (57.1) | 27 (42.9) | ||
| Family history of thyroid cancer | 12(100) | 0 (0) | 0.329 | 3 (25) | 9 (75) | 0.036 |
| History of smoking | 7 (100) | 0 (0) | 1.00 | 3 (42) | 4 (58) | 0.702 |
| Exposure to radiation | 3 (100) | 0 (0) | 1.00 | 1 (33) | 2 (66) | 0.598 |
| Histologic type | ||||||
| Classic (N = 42) | 38(90) | 4 (10) | 19 (45) | 23(55) | ||
| Microcarcinoma (N = 29) | 22(81) | 5(19) | 0.434 | 17 (63) | 10(37) | 0.01 |
| Follicular(N = 19) | 19 (90) | 2 (10) | 1.00 | 13 (58) | 8 (42) | 0.08 |
| Encapsulated with invasion(11) | 11 (100) | 0(0) | 9 (82) | 2(18) | ||
| Infiltrative (10) | 9 (90) | 1(10) | 1.00 | 6 (60) | 4(40) | 0.001 |
| Tumor size | ||||||
| T1(N = 49) | 43 (87.8) | 6(12.2) | 0.994 | 31(63.3) | 18(36.7) | 0.052 |
| T2(N = 22) | 20(90.9) | 2(9.1) | 0.611 | 12(54.5) | 10(45.5) | 0.594 |
| T3+T4(N = 19) | 16(84.2) | 3(15.8) | 0.598 | 6(31.6) | 13(68.4) | 0.023 |
| LN Metastasis | ||||||
| Yes (N = 23) | 20(87.0) | 3(13.0) | 0.572 | 6 (26) | 17(74) | 0.002 |
| Focality | ||||||
| Unifocal (N = 60) | 52(86.7) | 8(13.3) | 0.653 | 34(56.7 | 26(43.3) | 0.354 |
| Multifocal (N = 30) | 27(90.0) | 3(10.0) | 15(50.0) | 15(50.0) | ||
| Surgical margin | ||||||
| Positive (N = 22) | 19 (86.4) | 3(13.6) | 0.818 | 8(36.4) | 14(63.6) | 0.043 |
| Lymphovascular invasion | ||||||
| Yes (N = 13) | 11(84.6) | 2(15.4) | 0.710 | 5(38.5) | 8(61.5) | 0.171 |