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. 2020 Apr 21;15(4):e0231700. doi: 10.1371/journal.pone.0231700

Table 4. Clinical practice guidelines for the pharmacological treatment of depression: Subtypes of depression.

Recommendations/clinical practice guidelines Chilean CPG1 [21] Colombian CPG [22] England CPG [23] ICSI2 CPG [24] APA3 CPG [26] CANMAT4 CPG [25]
Subtypes of depression -
Chronic or dysthymia - - - - -
Combination of antidepressants and psychotherapy - - - - -
Beginning of pharmacological treatment (pure dysthymia) - - - - -
Depression with psychotic features - -
Contraindication of isolated psychotherapy - - - - - -
Indication of antipsychotic agents in combination with antidepressants - -
Catatonic - - - -
Benzodiazepines in combination with antidepressants - - - -
Barbiturates in combination with antidepressants - - - - -
Depression with atypical features - - -
Monoamine oxidase inhibitors - - - -
Selective serotonin reuptake inhibitors and bupropion - - - - -
No specific antidepressants have demonstrated superiority - - - - -
Depression with melancholic features - - - -
Serotonin and noradrenaline reuptake inhibitors and tricyclic antidepressants - - - - -
No specific antidepressants have demonstrated superiority - - - - -
Depression with seasonal pattern - - - - -
No specific antidepressants have demonstrated superiority - - - - -
Depression with somatic symptoms (fatigue) - - - - -
Mixed depression disorder - - - - -

1CPG = clinical practice guideline;

2ICSI = Institute for Clinical Systems Improvement;

3APA = American Psychiatry Association;

4CANMAT = Canadian Network for Mood and Anxiety Treatments.

● = CPG does contain topic; - = CPG does not contain topic.