Table 1.

Biological Characteristics and Profiles of Bradykinin Angioedema

	C1Inh-HAE		C1Inh-AAE	nC1Inh-HAE	ACEi-AAE
	HAE Type I	HAE Type II
C1Inh function	<50 %	< 50%	<50%	Normal	Normal
C1Inh	<50%	Normal	<50%	Normal	Normal
C4	Low	Low	Low	Normal	Normal
C1q	Normal	Normal	Low (70% of cases)	Normal	Normal
Anti-C1Inh Ab			Present (50% of cases)
Mutation	SERPING1	SERPING1	No	FXII, PLG, ANGPT1, KNG1	No

Abbreviations: AE, angioedema; C1Inh-HAE, hereditary AE with C1Inhibitor deficiency; C1Inh, C1 inhibitor, C1Inh-AAE, acquired AE with C1-inhibitor deficiency; nC1Inh-HAE, acquired angioedema with normal C1-inhibitor; ACEi-AAE, angiotensin-converting enzyme inhibitor-induced AE; Ab, antibody.