Table 6. Reasons for discontinuation (Unweighted).

Reasons for Discontinuation	Real-World Cohort (N = 107)	PALOMA-2 (N = 222)
Total discontinued, n (%)	49 (45.8)	161 (72.5)
Disease progression or death	36 (33.6)	127 (57.2)
Treatment-related AE/toxicity	7 (6.5)	9 (4.1)
Othera	4 (3.7)	22 (9.9)
Protocol violation	NA	3 (1.4)
Unknown	2 (1.9)	NA

AE = adverse event; NA, not applicable; SD = standard deviation.

^aFor patients in the real-world cohort, the reasons were as follows: other (n = 3 [2.8%]), patient request unrelated to toxicity or financial issues (n = 1 ([0.9%]). For patients in the PALOMA-2 cohort, the reasons were as follows: global deterioration of health status(n = 9 [4.1%]), refused to continue for reason other than AE (n = 9 [4.2%]), other (n = 4 [1.8%]).