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. 2020 Apr 17;13:3247–3257. doi: 10.2147/OTT.S242715

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© 2020 Li et al.

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MiR-148b was a target of LINC00346 in CRC. (A) The expression of miR-148b in normal tissues and CRC tissues was detected by qRT-PCR (N = 60). ***P < 0.001 vs Normal tissue; (B) the expression of miR-148b in FHC, HT29 and HCT116 cells was detected by qRT-PCR (N = 3). *P < 0.05 vs FHC; (C) the correlation between the expression of LINC00346 and miR-148b in CRC tissues (N = 60); (D) the target site of miR-148b on LINC00346 was predicated by TargetScan; (E) relative luciferase activity of HT29 and HCT116 cells was measured by dual-luciferase reporter assay (N = 3). ***P < 0.001 vs miR-NC; (F) the interaction between miR-148b and LINC00346 in HT29 and HCT116 cells was assessed by RNA pull down assay (N = 3). ***P < 0.001 vs Bio-NC; (G) the expression of miR-148b in HT29 and HCT116 cells was detected by qRT-PCR (N = 3). **P < 0.01 vs pcDNA-NC or BLANK; ^&&&P < 0.001 vs si-NC and BLANK. N represented biological replicates. All experiments were repeated three times.