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. 2020 Apr 17;15:2563–2582. doi: 10.2147/IJN.S243223

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© 2020 Li et al.

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Structure and drug transport route of BBB. (I) penetrating through the tight junctions; (II) passive diffusion across the endothelial cells; (III) carrier-mediated transport; (IV) adsorption-mediated transcytosis or endocytosis; and (V) receptor-mediated transcytosis.