Figure 5.

(A) Schematic illustration of biomimetic proteolipid BLIPO-ICG for crossing the BBB and active targeting delivery of orthotopic glioma. (a) Preparation process of BLIPO-ICG. (b) Schematic of BLIPO-ICG for crossing BBB and active targeting imaging. (B) In vivo PTT of BLIPO-ICG in orthotopic glioma-bearing mice. (a) Representative in vivo infrared thermal images of the brain region before and after 808 nm laser irradiation (1 W/cm², 5 min). CLIPO-ICG = CBLIPO-ICG = ICG 1 mg/kg. (b) Representative bioluminescent images of C6-Luc glioma-bearing mice in different groups. (c) Semiquantitative bioluminescent signal intensity in the brain. **p < 0.01 versus control. #p < 0.05 versus LIPO-ICG+laser. (d) H&E staining of brain sections of orthotopic glioma-bearing mice in all groups. Scale bar = 200 μm. Reprinted with permission from Jia Y, X Wang, D Hu, et al Phototheranostics: Active Targeting of Orthotopic Glioma Using Biomimetic Proteolipid Nanoparticles. ACS Nano. 2019; 13(1): 386–398. Copyright (2019) American Chemical Society.¹⁴²