Table 3. Gene clustering of the metastasis-associated PAN-ECM differentially expressed genes (DEGs) by WGCNA module analysis.
| Canonical pathway (IPA Knowledgebase database) | Metastasis PAN-ECM (241+) (z-score) |
Module 1 (77) (z-score+) | Module 2 (74) (z-score+) | Module 3 (164) (z-score+) | Module 4 (253) (z-score+) |
|---|---|---|---|---|---|
| GP6 signaling pathway | 4.15 | 2.11 | 1.41 | 0.00 | 0.00 |
| Dendritic cell maturation | 2.45 | 2.24 | 2.45 | 0.00 | 0.90 |
| Osteoarthritis pathway | 2.31 | 1.34 | 0.45 | ||
| Colorectal cancer metastasis signaling | 2.89 | 2.14 | |||
| Wnt/Î2-catenin signaling | 2.45 | -2.00 | 0.00 | ||
| Neuroinflammation signaling pathway | 2.45 | 0.00 | 1.73 | 0.00 | 0.30 |
| ILK signaling | 2.45 | 1.89 | |||
| Role of pattern recognition receptors in recognition of bacteria and viruses | 2.24 | 0.00 | 2.45 | 0.00 | 0.38 |
| Neuregulin signaling | 2.24 | 0.00 | 2.24 | 0.00 | |
| Signaling by Rho family GTPases | 2.00 | 0.00 | 2.53 | 0.00 | |
| IL-6 signaling | 2.00 | 3.00 | |||
| ErbB signaling | 2.00 | 0.00 | 2.71 | 0.00 | |
| Growth hormone signaling | 2.00 | 0.00 | 2.65 | ||
| Glioblastoma multiform signaling | 1.89 | 2.71 | |||
| Leukocyte extravasation signaling | 1.63 | 2.53 | -1.67 | ||
| HMGB1 signaling | 1.41 | 0.00 | 2.83 | ||
| IL-8 signaling | 1.34 | 0.00 | 3.46 | -1.00 | -0.71 |
| Role of NFAT in cardiac hypertrophy | 1.34 | 2.71 | |||
| eNOS signaling | 1.00 | 0.00 | 2.65 | ||
| FGF signaling | 0.82 | 0.00 | 2.65 | 0.00 | |
| Acute-phase response signaling | 0.45 | 2.45 | |||
| Gα12/13 signaling | -0.45 | 0.00 | 3.00 | ||
| RhoGDI signaling | -1.00 | -1.34 | |||
| LXR/RXR activation | -1.00 | 0.00 | 0.00 | 0.00 | 0.45 |
The canonical pathways involved in each modules was listed and sorted by z-score.
+Number of genes.