Table 1.

Main Differential Diagnoses to Exclude in Sarcoidosis

Sarcoidosis Subtype	Possible Differential Diagnosis
Mediastino pulmonary sarcoidosis	Tuberculosis and mycobacterial infections
	Hodgkin disease and non-Hodgkin’s lymphoma
	Histoplasmosis, coccidioidomycosis, aspergillosis
	Pneumoconiosis: chronic beryllium disease, titanium, aluminium, talc
	Hypersensitivity pneumonitis
	Drug reactions
	Granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis
Extra thoracic sarcoidosis	Tuberculosis and mycobacterial infections
	Whipple disease, bartonellosis, Q fever, brucellosis, syphilis, toxoplasmosis, fungal infections
	Hodgkin disease and non-Hodgkin’s lymphoma
	Tumor associated sarcoid reaction
	Crohn’s disease, primary biliary cirrhosis
	Drug induced sarcoidosis (interferon α and β, intravesical BCG therapy, TNFα inhibitors, immune check point inhibitors)
	Common variable immunodeficiency

Abbreviations: BCG, Bacillus Calmette et Guérin; TNF, tumor necrosis factor.