Table 3.

Baseline sea-level characteristics

	Placebo	Losartan	P value	ACE genotype and pair no.
				Female pairs				Male pairs
Age (years)	38.6±18.5	40.4±18.0	0.83	1	ID	ID	4	II	II
Body mass (kg)	74.1±11.5	66.7±13.3	0.71	2	ID	ID	5	II	II
Height (cm)	172.6±8.4	176.4±8.9	0.83	3	ID	ID	6	ID	ID
GFR (mL/min/1.73 m2)	88.0±15.2	90.8±15.8	0.69				7	ID	ID
eGFR (mL/min/1.73 m2)	87.8±15.3	90.8±15.9	0.68				8	ID	ID
Creatinine (μmol/L)*	84.5±24.0	81.0±31.0	0.58				9	DD	ID
							10	DD	DD

Baseline results were obtained at sea level and prior to the administration of placebo and losartan. Results for continuous variables are reported as mean±SD unless indicated by *, where values are reported as median ± IQR. ACE genotypes are presented as allelic variations (II, ID and DD). Significance was set to p value <0.05. No significant differences between groups were evident at baseline sea level. Subjects were equally matched for sex (men and women). All genotypes were observed and 90% matched.

eGFR, estimated glomerular filtration rate (calculated using the MDRD study equation); GFR, glomerular filtration rate; MDRD, Modification of Diet in Renal Disease.