Table 2:
Factors associated with preference for return of results in factorial vignettes
| Characteristic of Interest* | JHS† | FHS‡ | FHS Omni§ | |||
|---|---|---|---|---|---|---|
| Odds Ratio (95% CI) |
p-value | Odds Ratio (95% CI) |
p-value | Odds Ratio (95% CI) |
p-value | |
| High relative risk (vs. low) | 0.82 (0.59, 1.15) |
0.252 | 1.29 (.98, 1.71) |
0.090 | 0.89 (0.44, 1.82) |
0.755 |
| High absolute risk (vs. low) | 0.88 (0.63, 1.223) |
0.442 | 1.56 (1.18, 2.07) |
0.001 | 0.88 (0.43,1.78) |
0.716 |
| Death (vs. painless rash) | 0.92 (0.58, 1.48) |
0.739 | 0.72 (0.49, 1.06) |
0.109 | 1.60 (0.60, 4.29) |
0.346 |
| Memory loss (vs. painless rash) | 0.84 (0.53, 1.33) |
0.445 | .81 (0.55, 1.20) |
0.307 | 1.34 (0.51. 3.51) |
0.548 |
| Arthritis (vs. painless rash) | 1.04 (0.64, 1.68) |
0.880 | 0.98 (0.65, 1.47) |
0.948 | 1.51 (0.57, 3.97) |
0.408 |
| Can be prevented (vs. cannot be prevented) | 0.82 (0.59, 1.15) |
0.442 | 3.34 (2.49, 4.49) |
<0.0001 | 1.16 (0.57, 2.34) |
0.688 |
| Reproductive risk of 1 in 2 (vs. unlikely) | 1.22 (0.88, 1.71) |
0.236 | 1.38 (1.05, 1.83) |
0.021 | 1.42 (0.69, 2.92) |
0.333 |
| Attitude towards genetic testing (continuous, range 1-5) | 1.61 (1.29,2.00) |
<0.0001 | 2.32 (1.93, 2.78) |
<0.0001 | 1.79 (1.04, 3.10) |
0.037 |
| College graduate (vs. not) | 0.51 (0.33, 0.81) |
0.005 | 1.08 (0.75, 1.55) |
0.701 | 1.65 (0.52, 5.24) |
0.393 |
| Subjective numeracy (continuous, range 1-6) | 1.19 (1.00, 1.41) |
0.050 | 1.03 (0.89. 1.20) |
0.663 | 1.07 (0.73, 1.59) |
0.725 |
| Age (continuous) | 0.98 (0.96, 1.00) |
0.037 | .99 (0.98, 1.00) |
0.138 | 0.96 (0.92, 0.99) |
0.047 |
*
Odds ratios represent the adjusted relative odds of desiring return of results comparing subjects who differ only on the covariate of interest. For continuous covariates, odds ratios represent the adjusted relative odds of desiring return of results associated with a 1-point change in the covariate (or one-year increase in age). Odds ratios are derived from generalized linear mixed models that account for multiple responses per participant.
†
N= 2636 vignette responses from 906 JHS respondents; adjusted R2 0.045.
‡
N=2720 vignette responses from 922 FHS respondents; adjusted R2 0.12.
§
N=464 vignette responses from 156 FHS Omni respondents; adjusted R2=.049