Table 3:

Factors associated with preference for return of results in response to blood clot and Alzheimer’s disease vignettes

Characteristic of Interest	Blood Clot Odds Ratio (95% CI)*	p-value	Alzheimer’s Disease Odds Ratio (95% CI)†	p-value
Jackson Heart Study†
Number of valid responses	861		851
Attitude towards genetic testing‡	1.74 (1.30, 2.34)	0.0002	1.56 (1.20, 2.03)	0.001
No religious preference (vs. any or private)	0.43 (0.05, 3.67)	0.441	0.52 (0.06, 4.49)	0.551
Religious attendance more than once/week	0.67 (0.29, 1.55)	0.354	0.77 (0.39, 1.52)	0.452
College graduate or more	1.02 (0.55, 1.89)	0.955	0.52 (0.31, 0.87)	0.014
Framingham Heart Study§
Number of valid responses	861		854
Attitude towards genetic testing‡	1.99 (1.51, 2.62)	<0.0001	2.24 (1.80, 2.79)	<0.0001
No religious preference (vs. any or private)	0.42 (0.22, 0.83)	0.013	0.94 (0.50, 1.78)	0.854
Religious attendance more than once/week	0.93 (0.47, 1.83)	0.833	0.59 (0.37, 0.94)	0.025
College graduate or more	1.23 (0.71, 2.12)	0.455	1.11 (0.74, 1.68)	0.612
Framingham Heart Study-Omni∥
Number of valid responses	145		145
Attitude towards genetic testing‡	1.26 (0.65, 2.43)	0.500	1.39 (0.80, 2.43)	.0248
No religious preference (vs. any or private)	0.27 (0.04, 2.14)	0.217	0.55 (0.09, 3.41)	0.524
Religious attendance more than once/week	0.31 (0.06, 1.54)	0.153	0.55 (0.16, 1.86)	0.334
College graduate or more	1.29 (0.36, 4.66)	0.697	1.61 (0.54, 4.83)	0.395

^*Odds ratios represent the adjusted relative odds of desiring return of results comparing subjects who differ only on the covariate of interest. For continuous covariates, odds ratios represent the adjusted relative odds of desiring return of results associated with a 1-point change in the covariate.

^†Adjusted R² for JHS blood clot vignette was 0.0348; adjusted R² for JHS Alzheimer’s vignette was 0.0185.

^‡Possible range 1 (least favorable) to 5 (most favorable)

^§Adjusted R² for FHS blood clot vignette was 0.0579; adjusted R² for FHS Alzheimer’s vignette was 0.0954.

^∥Adjusted R² for FHS-Omni blood clot vignette was 0.0041; adjusted R² for FHS-Omni Alzheimer’s vignette was 0.0057