Table 3.
Variables associated with cancer-specific survival according to the Cox proportional hazards regression model
| Character | Univariable analysis | Multivariable analysis | ||
| HR (95 % CI) | P value | HR (95 % CI) | P value | |
| Age (years) | ||||
| <60 | Reference | – | Reference | – |
| ≥60 | 2.076 (1.341 to 3.212) | 0.001 | 1.651 (1.005 to 2.713) | 0.048 |
| Sex | ||||
| Male | Reference | – | ||
| Female | 0.710 (0.471 to 1.070) | 0.102 | ||
| Race | 0.983 | |||
| White | Reference | – | ||
| Black | 0.957 (0.554 to 1.651) | 0.873 | ||
| Others | 1.024 (0.527 to 1.993) | 0.943 | ||
| Marital status | 0.779 | |||
| Married | Reference | – | ||
| Unmarried | 0.851 (0.473 to 1.532) | 0.591 | ||
| Others | 1.083 (0.659 to 1.778) | 0.753 | ||
| Tumour site | 0.005 | 0.047 | ||
| Cardia/fundus | Reference | – | Reference | – |
| Greater curvature/lesser curvature/body | 0.480 (0.283 to 0.816) | 0.007 | 0.497 (0.271 to 0.912) | 0.024 |
| Pylorus/antrum | 0.775 (0.454 to 1.323) | 0.35 | 0.893 (0.491 to 1.624) | 0.710 |
| Others | 0.369 (0.192 to 0.710) | 0.003 | 0.428 (0.186 to 0.981) | 0.045 |
| Tumour size (cm) | ||||
| ≤5 | Reference | – | Reference | – |
| >5 | 3.947 (2.573 to 6.054) | <0.001 | 1.193 (0.727 to 1.957) | 0.484 |
| Differentiation | <0.001 | <0.001 | ||
| Well/moderate | Reference | – | Reference | – |
| Poor/undifferentiated | 6.546 (3.880 to 11.045) | <0.001 | 3.512 (1.804 to 6.836) | <0.001 |
| Unknown | 1.196 (0.537 to 2.662) | 0.662 | 1.244 (0.493 to 3.134) | 0.644 |
| T staging | <0.001 | 0.004 | ||
| T1 | Reference | – | Reference | – |
| T2 | 7.424 (1.790 to 30.789) | 0.006 | 1.737 (0.392 to 7.689) | 0.467 |
| T3 | 10.689 (2.513 to 45.461) | 0.001 | 1.860 (0.399 to 8.675) | 0.430 |
| T4 | 26.659 (6.350 to 111.923) | <0.001 | 4.406 (0.965 to 20.115) | 0.056 |
| M staging | ||||
| M0 | Reference | – | Reference | – |
| M1 | 3.629 (2.335 to 5.641) | <0.001 | 2.200 (1.318 to 3.674) | 0.003 |
| Surgery | ||||
| Performed | Reference | – | Reference | – |
| Not performed | 2.670 (1.080 to 6.605) | 0.034 | 7.511 (1.982 to 28.462) | 0.003 |
| LNR | <0.001 | <0.001 | ||
| 0 | Reference | – | Reference | – |
| ≤0.132 | 3.618 (1.745 to 7.499) | 0.001 | 3.085 (1.378 to 6.905) | 0.006 |
| >0.132 | 6.533 (3.720 to 11.474) | <0.001 | 4.980 (2.655 to 9.341) | <0.001 |
| Chemotherapy | ||||
| Performed | Reference | – | Reference | – |
| No/unknown | 0.374 (0.246 to 0.570) | <0.001 | 1.795 (1.045 to 3.082) | 0.034 |
| Radiotherapy | ||||
| Performed | Reference | — | Reference | — |
| Not performed | 0.416 (0.253 to 0.684) | 0.001 | 0.647 (0.359 to 1.168) | 0.149 |
LNR, lymph node ratio.