Table 3.

Current and potential candidate hypertensive populations for RDN therapy

Patient group	Pro	Con
Current candidates
Difficult-to-control hypertensive patients (with office SBP between 140 and 170 mmHg or DBP between 90 and 109 mmHg)	Current target population Solid evidence base	Narrow group
Potential candidates
CAD patients	Very high-risk patients Low rates of BP control in daily care	Prolonged procedure (PCI + RDN)
Cancer survivors	Many cancer treatments can induce hypertension HTN is a risk factor for the toxicity of other agent	Need for RDN not proven
HIV patients	Already under major pill burden Drug–drug interaction Previously neglected group	Recruitment challenges Need for RDN not proven
White-coat hypertension on medications   Masked hypertension off and on medications	High-risk groups Large population	Untested therapy in this population Uncertain reproducibility of current data on risk Not well-recognized as candidates Need for RDN not proven
White-coat hypertension off medications	Many will develop chronic hypertension Large population	Untested therapy in this population Uncertain reproducibility of current data on risk Not well-recognized as candidates Unmet need not proven

CAD, coronary artery disease; HIV, human immunodeficiency virus; HTN, hypertension; PCI, percutaneous coronary intervention.