Table 1.
Clinical characteristics
| Variables | Entire cohort (n=390) |
PIIINP at discharge (n=384) | P4NP 7S at discharge (n=390) | ||||
| Low (n=193) | High (n=191) | P value | Low (n=200) | High (n=190) | P value | ||
| Clinical characteristics | |||||||
| Age (years) | 76.2±11.5 | 75.2±11.4 | 77.5±11.4 | 0.046 | 78.8±10.8 | 73.4±11.7 | <0.0001 |
| Male | 207 (53) | 107 (55) | 95 (50) | 0.26 | 94 (47) | 113 (59) | 0.014 |
| Hypertension | 301 (77) | 143 (74) | 154 (81) | 0.13 | 156 (78) | 145 (76) | 0.69 |
| Diabetes mellitus | 138 (35) | 65 (34) | 71 (37) | 0.5 | 63 (32) | 75 (39) | 0.11 |
| Ischaemic heart disease | 112 (29) | 54 (28) | 56 (29) | 0.77 | 64 (32) | 48 (29) | 0.14 |
| EF<40% | 154 (39) | 89 (46) | 62 (32) | 0.0061 | 74 (37) | 80 (42) | 0.3 |
| Anaemia | 242 (63) | 98 (51) | 143 (75) | <0.0001 | 137 (69) | 105 (56) | 0.008 |
| Medication at discharge | |||||||
| β-blocker | 304 (78) | 160 (83) | 138 (73) | 0.016 | 152 (76) | 152 (80) | 0.29 |
| ACEI or ARB | 241 (62) | 128 (66) | 108 (57) | 0.049 | 124 (62) | 117 (62) | 0.93 |
| MRA | 208 (53) | 101 (52) | 104 (54) | 0.68 | 95 (48) | 113 (59) | 0.018 |
| Loop diuretics | 344 (88) | 164 (85) | 174 (91) | 0.08 | 172 (86) | 172 (91) | 0.21 |
| Laboratory tests at discharge | |||||||
| T-Bil (mg/dL) | 0.6 (0.5–0.9) | 0.7 (0.5–1) | 0.6 (0.4–0.8) | 0.0001 | 0.5 (04–0.7) | 0.8 (0.6–1.1) | <0.0001 |
| AST (U/L) | 22 (17–29) | 23 (18–31) | 22 (17–28) | 0.055 | 20 (17–25) | 25 (19–32) | <0.0001 |
| ALP (U/L) | 234 (190–303) | 231 (186–300) | 238 (194–317) | 0.098 | 225 (186–288) | 243 (198–333) | 0.0094 |
| γ-GTP (U/L) | 33 (19–67) | 37 (22–70) | 27 (17–63) | 0.66 | 24 (17–41) | 52 (26–90) | <0.0001 |
| Albumin (g/dL) | 3.5 (3.1–3.8) | 3.5 (3.2–3.9) | 3.5 (3–3.75) | 0.13 | 3.5 (3.1–3.8) | 3.5 (3.2–3.8) | 0.25 |
| eGFR (mL/min/1.73 m2) | 47.2±20.2 | 53.6±18.6 | 40.1±19.2 | <0.0001 | 40 (28–58) | 48 (34–60) | 0.031 |
| BNP (pg/mL) | 266 (121–480) | 258 (103–443) | 268 (131–585) | 0.2 | 207 (96–397) | 293 (171–667) | <0.0001 |
| PIIINP (U/mL) | 0.71 (0.58–0.93) | 0.58 (0.51–0.64) | 0.93 (0.81–1.1) | <0.0001 | 0.67 (0.55–0.86) | 0.77 (0.61–1) | 0.0019 |
| P4NP 7S (ng/mL) | 5.1 (4.1–6.5) | 4.7 (3.8–6) | 5.6 (4.4–7) | <0.0001 | 4.1 (3.4–4.6) | 6.6 (5.8–7.6) | <0.0001 |
Values are number (%), mean (SD) or median (IQR).
ACE-I, angiotensin-converting enzyme inhibitor; ALP, alkaline phosphatase; ARB, angiotensin receptor blocker; AST, aspartate aminotransferase; BNP, brain natriuretic peptide; EF, ejection fraction; eGFR, estimated glomerular filtration rate; γ-GTP, γ-glutamyltransferase; MRA, mineral conrticoid receptor antagonist; PIIINP, N-terminal propeptide of procollagen type III; P4NP 7S, 7S domain of the collagen type IV N-terminal propeptide; T-Bil, total bilirubin.