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. 2020 Apr 1;8(1):e000166. doi: 10.1136/jitc-2019-000166

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Cross-reactivity of ACT products. The recognition of shared antigens was investigated using a panel of melanoma cell lines that share at least one HLA class I allele. Recognition of allogeneic cell lines is defined as cross-reactivity. The percentage cross-reactivity is depicted and calculated by division of number of cell lines recognized by the number of cell lines tested×100%. Results for TRT (n=7) and TIL (n=14) are depicted. Representative examples of three ACT products with a relatively high or low percentage cross-reactivity are depicted (A–C). (A) A high percentage cross-reactivity was observed for TIL of patient 15.17, who was progressive on treatment and had an OS of 8 months. (B) Shows a rather restricted recognition pattern for TRT of patient 09.10 who obtained stabilization of disease and a relatively long OS, while (C) shows the recognition pattern of TIL from a complete responder 16.12, who only recognizes the positive control (SEB). Asterisk (*) indicates the autologous cell line of patient 09.10. ACT, adoptive cell therapy; CR, complete response; HLA, human leukocyte antigen; IFN, interferon; OS, overall survival; PD, progressive disease; PR, partial response; SD, stable disease; SEB, SEB, staphylococcal enterotoxin B; TIL, tumor infiltrating T cells; TRT, tumor-reactive T cells.