Figure 5.

Growth curves of subcutaneously implanted syngeneic cancer cells into wild-type (WT) mice prophylactically infused with soluble human CD6 (shCD6) protein. B16.F0 (5×10⁴), MCA205 (5×10⁴), EL-4 (5×10⁴), and RMA-S (5×10⁴) cells were subcutaneously injected into WT mice receiving intraperitoneal injections of shCD6 (1.25 mg/kg) or vehicle (PBS 10% glycerol) every other day from tumor implantation. Tumor growth (area in mm²) and weight (GR) were measured every other day and at sacrifice, respectively. Two-way analysis of variance and Mann-Whitney tests were used for statistical analysis of tumor growth and weight, respectively. Data are presented as mean±SE.