Table 1. Demographics and clinical characteristics of the study population.
| Variable | MCI (n=59) | aMCI (n=38) | naMCI (n=21) | NC (n=37) |
|---|---|---|---|---|
| Age, years | 69.6±9.24* | 70.1±8.08 | 68.5±11.19 | 64.6±11.68 |
| Age at onset, years | 66.8±9.25 | 67.8±7.88 | 65.1±11.34 | - |
| Sex, female | 40 (67.8) | 27 (71.1) | 13 (61.9) | 20 (54.1) |
| Education, years | 7.66±4.81* | 7.81±4.60* | 7.40±5.29* | 11.95±4.47 |
| Disease duration, months | 35.8±16.34 | 30.7±15.90 | 39.3±16.04 | - |
| MMSE score | 24.5±3.96* | 23.9±4.18* | 25.6±3.33* | 28.4±1.76 |
| CDR-SOB score | 1.26±1.19* | 1.63±1.32* | 0.59±0.43* | 0.00±0.00 |
| APOE ε4 carrier | 21 (35.6) | 14 (36.8) | 7 (33.4) | 8 (21.6) |
| Amyloid positivity | 14/25 (56.0) | 12/19 (63.2) | 2/6 (33.3) | 0 (0) |
| Hypertension | 29 (49.2) | 15 (39.5) | 14 (66.7) | 12 (32.4) |
| Diabetes mellitus | 10 (16.9) | 5 (13.2) | 5 (23.8) | 3 (8.1) |
| Coronary artery disease | 7 (11.9) | 3 (7.9) | 4 (19.0) | 3 (8.1) |
| Dyslipidemia | 21 (35.6) | 9 (23.7) | 12 (57.10) | 13 (35.1) |
| History of stroke | 6 (10.2) | 3 (7.9) | 3 (14.3) | 0 (0) |
| Total lacunes | 0.85±0.97 | 0.71±0.80 | 1.10±1.12 | 0.62±0.75 |
| Total microbleeds | 0.36±2.22 | 0.55±2.76 | 0.00±0.00 | 0.08±0.36 |
| Total WMH volume, mm3 | 8,922±13,144* | 10,321±15,426* | 6,657±8,071 | 3,122±4,268 |
| PWMH volume, mm3 | 7,390±10,043* | 8,422±11,561* | 5,719±6,859 | 2,763±3,634 |
| DWMH volume, mm3 | 1,532±3,866* | 1,898±4,726 | 938±1702 | 360±815 |
| Mean cortical thickness, mm | 2.42±0.08* | 2.41±0.07* | 2.44±0.10 | 2.49±0.07 |
| Hippocampal volume, mm3 | 3,565±619* | 3,457±616* | 3,761±588* | 4,160±397 |
| Intracranial volume, mm3 | 1.39×106±1.92×105 | 1.40×106±1.92×105 | 1.38×106±1.98×105 | 1.37×106±1.66×105 |
Data are mean±SD values for continuous variables and n (%) values for categorical variables.
*p<0.05 versus NC in independent t-test for continuous variables and chi-square test for categorical variables.
aMCI: amnestic MCI, CDR-SOB: Clinical Dementia Rating–Sum of Boxes, DWMH: deep WMH, MCI: mild cognitive impairment, MMSE: Mini Mental State Examination, naMCI: nonamnestic MCI, NC: normal cognition, PWMH: periventricular WMH, WMH: white-matter hyperintensity.