Table 4. Regional standardized uptake value ratio (SUVR) in [18F]THK5351 positron emission tomography of aMCI subgroups and the NC group.
| Region | Right cerebral hemisphere | Left cerebral hemisphere | ||||||
|---|---|---|---|---|---|---|---|---|
| Verbal-aMCI (n=12) | Visual-aMCI (n=10) | Both-aMCI (n=16) | NC (n=37) | Verbal-aMCI (n=12) | Visual-aMCI (n=10) | Both-aMCI (n=16) | NC (n=37) | |
| Prefrontal | 1.81±0.47* | 1.65±0.31 | 1.92±0.32* | 1.47±0.25 | 1.74±0.35 | 1.65±0.29 | 1.99±0.47* | 1.47±0.23 |
| Orbitofrontal | 2.37±0.65* | 2.10±0.40 | 2.41±0.33* | 1.93±0.33 | 2.24±0.53 | 2.12±0.36 | 2.50±0.51* | 1.90±0.32 |
| Sensorimotor | 1.26±0.17 | 1.22±0.20 | 1.34±0.23* | 1.16±0.20 | 1.27±0.18 | 1.27±0.18 | 1.38±0.24* | 1.17±0.20 |
| Anterior cingulate | 3.24±0.70 | 3.03±0.63 | 3.29±0.38 | 2.96±0.41 | 3.21±0.58 | 2.96±0.64 | 3.46±0.54* | 2.97±0.46 |
| Superior parietal | 1.46±0.26 | 1.49±0.31 | 1.73±0.41* | 1.28±0.22 | 1.45±0.20 | 1.43±0.29 | 1.78±0.43* | 1.25±0.19 |
| Inferior parietal | 1.68±0.29*, † | 1.68±0.35 | 1.93±0.32* | 1.41±0.24 | 1.67±0.32 | 1.65±0.32 | 2.08±0.52* | 1.40±0.25 |
| Precuneus | 1.79±0.30 | 1.76±0.39 | 2.17±0.40* | 1.52±0.26 | 1.80±0.31 | 1.81±0.35 | 2.29±0.52* | 1.55±0.25 |
| Posterior cingulate | 2.25±0.38 | 1.72±1.17 | 2.53±0.33* | 1.94±0.27 | 2.25±0.43 | 2.07±0.45 | 2.56±0.43* | 1.94±0.27 |
| Occipital | 1.40±0.20* | 1.36±0.41 | 1.40±0.40* | 1.12±0.19 | 1.31±0.26 | 1.23±0.25 | 1.34±0.48* | 1.06±0.17 |
| Superior temporal | 1.86±0.28 | 1.92±0.35 | 2.05±0.29* | 1.70±0.26 | 1.85±0.30 | 1.94±0.35 | 2.16±0.46* | 1.70±0.31 |
| Middle temporal | 2.16±0.50* | 2.00±0.40 | 2.30±0.34* | 1.72±0.29 | 2.06±0.52 | 1.97±0.43 | 2.37±0.60* | 1.69±0.32 |
| Inferior temporal | 2.10±0.52* | 1.99±0.51 | 2.27±0.36* | 1.69±0.29 | 2.03±0.43 | 1.95±0.44 | 2.36±0.51* | 1.67±0.31 |
| Mesial temporal | 3.15±0.93* | 2.76±0.51 | 3.29±0.55* | 2.52±0.31 | 2.95±0.63*, † | 2.71±0.38 | 3.36±0.62* | 2.50±0.33 |
| Entorhinal | 2.93±1.27* | 2.48±0.73 | 2.90±0.65* | 2.18±0.39 | 2.62±0.57 | 2.40±0.48 | 3.08±0.75* | 2.23±0.42 |
| Parahippocampus | 2.28±0.40 | 2.15±0.35 | 2.58±0.41* | 1.96±0.35 | 2.31±0.38 | 2.21±0.38 | 2.79±0.67* | 2.04±0.42 |
| Hippocampus | 3.09±0.84* | 2.76±0.50 | 3.28±0.58* | 2.55±0.30 | 2.93±0.70*, † | 2.71±0.35 | 3.27±0.52* | 2.49±0.29 |
| Amygdala | 4.72±1.67* | 3.77±0.77 | 4.73±1.40* | 3.36±0.52 | 4.15±1.12*, † | 3.66±0.59 | 4.62±1.01* | 3.28±0.44 |
| Fusiform gyrus | 1.83±0.30 | 1.87±0.55 | 2.05±0.39* | 1.56±0.24 | 1.87±0.32 | 1.85±0.36 | 2.26±0.70* | 1.61±0.25 |
| Lingual gyrus | 1.41±0.23 | 1.28±0.38 | 1.44±0.36* | 1.20±0.21 | 1.54±0.27*, † | 1.37±0.33 | 1.45±0.43 | 1.24±0.24 |
| Striatum | 3.60±0.88 | 3.48±0.51 | 3.50±0.57 | 3.15±0.51 | 3.48±0.87 | 3.35±0.47 | 3.52±0.62 | 3.07±0.51 |
| Global cortex | 1.87±0.34* | 1.78±0.33 | 2.03±0.31* | 1.57±0.24 | 1.83±0.31 | 1.76±0.30 | 2.11±0.43* | 1.56±0.23 |
Data are mean±SD values. One-way analysis of covariance with adjustment for age and years of education.
*p<0.05 versus NC, †Regions in which statistical significance was lost after region-wise correction for multiple comparisons.
aMCI: amnestic MCI, Both-aMCI: MCI with both visual and verbal memory impairment, MCI: mild cognitive impairment, NC: normal cognition, VerbalaMCI: MCI with verbal memory impairment, Visual-aMCI: MCI with visual memory impairment.