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Proposed mechanisms by which the H3K27M mutation changes the epigenetic landscape and impacts transcription, including (A) inactivation of PRC2 leading to H3K27me3 loss, (B) conversion of bivalent to active promoters, (C) selective retention of H3K27me3 (purple dots in scatter plot), (D) altered spreading of histone marks and (E) increased propensity for ERV expression.
