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. 2020 Apr 7;8(1):e000655. doi: 10.1136/jitc-2020-000655

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

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Cell densities in prevaccination biopsies (Pre) and in radical prostatectomy sections postvaccination (Post) with PROSTVAC. (A) Representative image of multiplex immunofluorescence panel. Insets show a cell expressing four markers (CD4, FOXP3, Ki67 and DAPI). (B) Immune-cell infiltrates were quantified in both prevaccination and postvaccination sections using inForm software. NCA of both CD4 and CD8 immune-cell density ratios was assessed by the Wilcoxon signed rank test. Median±IQR shown with horizontal lines. (C) Exceptional case with CD4 and CD8 immune-cell infiltrates prevaccination and postvaccination. CTL, cytotoxic T lymphocyte; NCA, non-compartmentalized analysis; PD-L1, programmed death-ligand 1; Th, T helper; TIME: tumor immune microenvironment.