Table 1.

Ongoing or recently completed human clinical trials testing neutralizing antibody potential and structure-based vaccine design concepts

Clinical trial #	Pathogen	Primary outcome
NCT03049488	RSV	Evaluate stabilized RSV pre-F vaccine for induction of neutralizing antibodies
NCT03300050	Influenza	Evaluate chimeric HA trimers for immuno-focusing on stalk epitope
NCT03814720	Influenza	Evaluate mini HA trimers for immuno-focusing on stalk epitope
NCT02825797	HIV	Evaluate the ability of a bnAb combination to suppress viremia in HIV positive individuals
NCT02716675	HIV	Evaluate the ability of a bnAb monotherapy to prevent HIV acquisition
NCT02568215	HIV	Evaluate the ability of a bnAb monotherapy to prevent HIV acquisition
NCT03699241	HIV	Evaluate stabilized HIV Env trimers for induction of neutralizing antibodies
NCT04177355	HIV	Evaluate stabilized HIV Env trimers for induction of neutralizing antibodies
NCT03783130	HIV	Evaluate stabilized HIV Env trimers for induction of neutralizing antibodies
NCT03547245	HIV	Evaluate germline targeting immunogen to prime and expand rare B cell bnAb precursors