Table 2.

Effects of 3 mg/g hispidin‐enriched Sanghuangporus sanghuang mycelia in chromosomal aberration in CHO‐K1 cells

Dose (%)	S9‐Mixure	G	B	D	R	g	b	Int	Itr	Other	AFa
Short‐term treatment (3 hr)
Negative controlb	+	0	0	0	0	0	0	0	0	0	0/200
Positive controlc	+	0	3	13	0	0	5	4	1	0	26/200*
S. sanghuang mycelia 1.25	+	0	1	0	0	0	0	0	0	0	1/200
S. sanghuang mycelia 0.625	+	0	0	0	1	0	1	0	0	0	2/200
S. sanghuang mycelia 0.3125	+	0	0	0	0	0	0	0	0	0	0/200
Negative controlb	−	0	0	0	0	0	0	0	0	0	0/200
Positive controld	−	0	3	2	1	0	6	23	4	0	39/200*
S. sanghuang mycelia 5	−	0	0	0	0	0	0	0	0	0	0/200
S. sanghuang mycelia 2.5	−	0	0	0	0	0	0	0	0	0	0/200
S. sanghuang mycelia 1.25	−	0	0	0	0	0	0	0	0	0	0/200
Long‐term treatment (20 hr)
Negative controlb	−	0	0	0	0	0	0	0	0	0	0/200
Positive controld	−	0	1	3	0	0	11	10	3	0	28/200*
S. sanghuang mycelia 5	−	0	0	0	0	0	0	0	0	0	0/200
S. sanghuang mycelia 2.5	−	0	0	0	0	0	0	0	0	0	0/200
S. sanghuang mycelia 1.25	−	0	0	0	0	0	1	0	0	0	1/200

Chromosome gaps were recorded separately but not included in aberrant cells. b, chromatid break; B, chromosome break; D, dicentric; g, chromatid gap; G, chromosome gap; Int, interchange; Itr, intrachange; R, ring.

^aAberration frequency: Number of cells with chromosome aberration in 200 metaphase cells (n/200).

^bHam's F‐12 Culture medium with 10% fetal bovine serum.

^c25 μg/ml cyclophosphamide.

^d2 μg/ml mitomycin C.

^*Statistically significant (p < .05) when compared to the control group.