Table 3.
Number of patients with bleeding or spotting by treatment cycle and period
| Cycle | DRSP 4 mg n/m (%) |
DSG 0.075 mg n/m (%) |
Difference (95% CI) | Chi square test p value |
|---|---|---|---|---|
| Cycle 1 | 692/765 (90.5) | 284/305 (93.1) | − 2.66 (− 6.18, 0.87) | 0.1657 |
| Cycle 2 | 482/692 (69.7) | 211/285 (74.0) | − 4.38 (− 10.5; 1.75) | 0.1704 |
| Cycle 3 | 429/637 (67.3) | 160/251 (63.7) | 3.60 (− 3.37; 10.58) | 0.3064 |
| Cycle 4 | 390/606 (64.4) | 161/244 (66.0) | − 1.63 (− 8.69; 5.44) | 0.6531 |
| Cycle 5 | 351/566 (62.0) | 118/219 (53.9) | 8.13 (0.41; 15.85) | 0.0372 |
| Cycle 6 | 305/530 (57.5) | 110/199 (55.3) | 2.27 (− 5.82; 10.36) | 0.5812 |
| Cycle 7 | 292/503 (58.1) | 91/185 (49.2) | 8.86 (0.47; 17.26) | 0.0380 |
| Cycle 8 | 264/468 (56.4) | 87/178 (48.9) | 7.53 (− 1.07; 16.14) | 0.0859 |
| Cycle 9 | 249/442 (56.3) | 73/161 (45.3) | 10.99 (2.02; 19.97) | 0.0167 |
| Cycles 2–4 | 421/527 (79.9) | 192/222 (86.5) | − 6.60 (− 12.3; − 0.95) | 0.0324 |
| Cycles 5–7 | 313/423 (74.0) | 106/157 (67.5) | 6.48 (− 1.95; 14.91) | 0.1216 |
| Cycles 7–9 | 274/374 (73.3) | 93/137 (67.9) | 5.38 (− 3.64; 14.39) | 0.2312 |
| Cycles 2–6 | 346/422 (82.0) | 152/172 (88.4) | − 6.38 (− 12.4; − 0.35) | 0.0553 |
| Cycles 2–9 | 256/305 (83.9) | 102/116 (87.9) | − 4.00 (− 11.2; 3.22) | 0.3044 |
n number of subjects with data available, m number of subjects in respective cycle, % percentage based on m, CI confidence interval