Table 6.

Multiple Cox regression models inclusive of biplane and SAX LAEF for the composite endpoint of death and/or hospitalization with heart failure

Cox proportional hazard regression predictors of outcome
Including biplane LAEF			Including SAX LAEF
	Hazard ratio (95%CI)	P value		Hazard ratio (95%CI)	P value
Clinical
Age	1.126 (0.771–1.645)	0.538	Age	1.049 (0.708–1.555)	0.811
Average diastolic BP	0.606 (0.407–0.904)	0.014	Average diastolic BP	0.580 (0.390–0.863)	0.007
Prior HF hospitalization	1.693 (0.810–3.540)	0.162	Prior HF hospitalization	1.588 (0.754–3.347)	0.224
6MWT distance	0.596 (0.372–0.956)	0.032	6MWT distance	0.613 (0.387–0.972)	0.038
+ Biplane LAEF	0.535 (0.385–0.744)	< 0.0001	+ SAX LAEF	0.532 (0.391–0.724)	< 0.0001
Clinical blood samples
Log creatinine (umol/L)	1.035 (0.731–1.466)	0.0847	Log creatinine (umol/L)	1.033 (0.734–1.454)	0.853
Haemoglobin (g/L)	0.805 (0.584–1.109)	0.155	Haemoglobin (g/L)	0.677 (0.496–0.923)	0.114
Log BNP (ng/L)	1.126 (0.712–1.782)	0.611	Log BNP (ng/L)	1.128 (0.712–1.787)	0.607
Log NTpro-ANP	1.373 (0.990–1.906)	0.058	NTpro-ANP	1.244 (0.890–1.739)	0.202
+ Biplane LAEF	0.649 (0.456–0.924)	0.016	+ SAX LAEF	0.552 (0.410–0.741)	< 0.0001
Imaging
LV mass index	0.582 (0.217–1.560)	0.282	LV mass index	0.529 (0.205–1.366)	0.188
LAVI max	0.961 (0.599–1.541)	0.869	LAVI max	0.997 (0.630–1.577)	0.988
iECV	1.558 (1.097–2.213)	0.013	iECV	1.564 (1.106–2.211)	0.011
+ Biplane LAEF	0.575 (0.419–0.788)	0.001	+ SAX LAEF	0.668 (0.472–0.944)	0.022
Strongest markers combined
Average diastolic BP	0.723 (0.461–1.134)	0.158	Average diastolic BP	0.725 (0.461–1.139)	0.163
6MWT distance	0.611 (0.354–1.053)	0.076	6MWT distance	0.592 (0.346–1.011)	0.055
iECV	1.491 (1.038–2.143)	0.031	iECV	1.584 (1.110–2.260)	0.011
+ Biplane LAEF	0.604 (0.406–0.900)	0.013	+ SAX LAEF	0.636 (0.441–0.918)	0.016