Figure 7. miR-148a regulated ERK/MAPK signaling pathway through targeting IGF-IR.

Compared with miR-148a transfection, the co-transfection of miR-148a mimic and IGF-IR overexpression could significantly enhance the expression of p-MEK1, p-ERK, p-MAPK and p-JNKL, suggesting the activation of ERK/MAPK pathway. *: P<0.05, **: P<0.01.