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. 2020 Apr 21;10:6772. doi: 10.1038/s41598-020-63841-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Downregulation of DBC1 in Vascular Smooth Muscle Cells (VSMC), increases the expression of aortic dissection (AD) markers. (A) Immunofluorescence image of VSMC purified and cultured from abdominal aorta using alpha-actin antibody (green), marker of VSMC. Left, panoramic view (100×) showing purity of the culture. Right, high magnification (630×) showing alpha-actin filaments in VSMC. Scale bar: 15 µm. (B) Representative western blot for DBC1 expression in proliferating VSMC purified from WT and DBC1 KO mice. (C,D) mRNA expression of MMP9 and MMP12 in WT and DBC1 KO VSMC, treated with vehicle (C) or 100 nM ANGII for 12 h. The results are shown as the mean ± SEM from at least 3 independent experiments. One-way ANOVA with Bonferroni’s post hoc test for multiple comparisons was done. *,** and *** means P < 0.05, 0.01 and 0.001, respectively.