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. 2020 Apr 21;10:6771. doi: 10.1038/s41598-020-63496-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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PRP treatment promotes migration, proliferation and induced osteogenic differentiation of M-MSCs in vitro. (A,B) Transwell assay displayed that after PRP treatment, the number of migrated M-MSCs was significantly increased. 10 randomized fields of view for each group. scale bar = 20 μm. (C) CCK8 assay displayed that after PRP treatment, cellular growth was significantly enhanced. (D,E) Western blot analysis displayed compared with M-MSCs treated with FBS, PRP treatment increased the expression of Cbfa-1 and Coll I while decreased the expression of MyoD1. (F) ALP activity detection revealed PRP treatment significantly elevated ALP activity in differentiated M-MSCs. *P < 0.05, **P < 0.01.