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. 2020 Apr 21;10:6676. doi: 10.1038/s41598-020-63631-2

Table 2.

The KEGG pathway enrichment analysis.

Gene name Description log2 Fold Change Corrected p-value
Vitamin B6 metabolism 4.54×10−4
SNO3 putative pyridoxal 5′-phosphate synthase +1.01 1.08×10−5
SNZ2 GMP synthase activity +1.46 3.15×10−40
SNZ3 Pyridoxal-5′-phosphate synthase +1.48 1.34×10−28
SNO2 putative pyridoxal 5′-phosphate synthase +1.75 2.67×10−40
Thiamine metabolism 8.15×10
THI80 thiamine diphosphokinase activity +1.23 4.34×10−20
THI21 phosphomethylpyrimidine kinase activity +1.54 7.4×10−18
THI5 Protein involved in synthesis of the thiamine precursor HMP +1.08 1.39×10−4
THI6 thiamine-phosphate diphosphorylase activity +1.21 9.36×10−18
THI20 phosphomethylpyrimidine kinase activity +1.14 2.12×10−13
THI22 hydroxymethylpyrimidine phosphate kinases +1.39 1.51×10−15
THI72 Transporter of thiamine or related compound +1.12 5.67×10−10
Arginine and proline metabolism 6.43×10
CAR1 arginase −2.10 2.28×10−32
CAR2 L-ornithine transaminase +1.04 4.91×10−8
PUT2 δ−1-pyrroline-5-carboxylate dehydrogenase −1.00 1.44×10−10
PUT4 Proline permease −5.40 1.72×10−147
PRO2 γ-glutamyl phosphate reductase −1.26 3.12×10−17
GAP1 Amino acid permease −2.09 3.23×10−18
SPE1 Ornithine decarboxylase −1.23 3.73×10−15
Aminoacyl-tRNA biosynthesis 5.09×10
MSE1 glutamate-tRNA ligase activity +1.84 5.04×10−50
MSW1 tryptophan-tRNA ligase activity +1.38 1.34×10−32
MSM1 methionine-tRNA ligase activity +1.69 6.71×10−32
MSF1 phenylalanine-tRNA ligase activity +1.60 1.76×10−30
MSD1 aminoacyl-tRNA ligase activity +1.34 9.97×10−28
AIM10 proline-tRNA ligase activity +1.42 3.10×10−25
HER2 glutaminyl-tRNA synthase activity +1.12 3.00×10−17
DIA4 serine-tRNA ligase activity +1.56 8.10×10−17
TYS1 tyrosine-tRNA ligase activity −1.42 8.10×10−17
KRS1 lysine-tRNA ligase activity −1.34 5.02×10−9
CDC60 leucine-tRNA ligase activity −1.42 5.11×10−9
THS1 threonine-tRNA ligase activity −1.20 6.05×10−9
DPS1 aspartate-tRNA ligase activity −1.15 1.05×10−8
DED81 asparagine-tRNA ligase activity −1.20 1.17×10−8
ALA1 alanine-tRNA ligase activity −1.19 6.36×10−8
FRS1 phenylalanine-tRNA ligase activity −1.01 4.96×10−7
GLN4 glutamine-tRNA ligase activity −1.03 9.35×10−5
Starch and sucrose metabolism 4.56×10
GSC2 1,3-beta-D-glucan synthase activity +1.89 1.43×10−9
DSE4 glucan endo-1,4-beta-glucanase activity +1.36 8.55×10−21
Steroid biosynthesis 1.48×10
ERG26 C-3 sterol dehydrogenase +1.14 1.55×10−11
ERG5 oxidoreductase activity +1.26 7.52×10−8
ERG3 oxidoreductase activity +1.25 2.11×10−7
ERG4 oxidoreductase activity +2.13 6.11×10−23
ERG28 ergosterol biosynthesis +1.77 2.81×10−10

The column of “log2 Fold Change” represents the base-two logarithm value of the fold change of the gene expression; “+” means up-regulated genes; “−” means down-regulated genes. Hypergeometric test was used for statistical analysis. The p-values have been corrected for multiple testing by the Benjamini and Hochberg adjustment method. The corrected p value <0.05 plus the absolute log2 Fold Change value >1 were considered statistically significant.