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. 2020 Apr 21;10:6722. doi: 10.1038/s41598-020-63663-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Human ZVV analysis results showing the binned means and standard errors of R and E as a function of F_R (solid lines) and V_T (bar chart insets) for both the first and second halves of the time recording (T1 and T2). Notice that the lowest F_R in patient 2 was greater than the highest F_R in all other patients. Note also that the error bars are often smaller than the symbols. (*): significance between V_T within same T. (^) and (#): significance from T1 to T2 for V_T,1 and V_T,2 (V_T,2 > V_T,1).