Figure 3.

Mouse ZVV analysis results showing the means and standard errors of R and E as a function of F_R and V_T (bar charts insets) for T1 and T2 before (solid lines) and after (dashed lines) lavage. With respect to F_R, R showed a decrease in all mice, while E increased in 4 out of 5 mice before and after lavage. With respect to V_T, expect for mouse 1, R increased while E decreased significantly with increasing V_T both in T1 and T2 before and after lavage. Following lavage, E increased in all mice while R was subject specific either decreasing or increasing. However, the effect of T on E before and after lavage was different (Supplementary Table S3). Although the percent changes were small (<10%), they were statistically significant in 4 out of 5 mice. (*): Significance between V_T within same T. (^) and (#): significance between T1 and T2 for V_T,1 and V_T,2 before lavage. (*) and (^): significance between T1 and T2 for V_T,1 and V_T,2 after lavage. (<) and (+): significance before and after lavage during T1 for V_T,1 and V_T,2. (—) and (>): significance before and after lavage during T2 for V_T,1 and V_T,2.