Table 1.
Association analyses of haplotype blocks.
| Haplotype | Frequency % | HaploScore | sim. p-value |
|---|---|---|---|
| a: haplotype block 2: antisaccade eye movement | |||
| GAGTAG | 8.6 | −3.103 | 1.0 × 10−3# |
| GACTTT | 52.5 | −0.671 | 5.1 × 10−1 |
| TACTTT | 7.0 | 0.183 | 8.6 × 10−1 |
| TGCCTT | 21.3 | 1.347 | 1.8 × 10−1 |
| GAGTAT | 1.6 | 1.370 | 1.8 × 10−1 |
| GAGTTT | 8.0 | 1.441 | 1.5 × 10−1 |
| b: haplotype block 2: mRNA expression | |||
| GAGTAG | 7.4 | −2.029 | 4.1 × 10−2 |
| GAGTAT | 1.1 | −1.083 | 3.0 × 10−1 |
| TGCCTT | 25.3 | −0.449 | 6.5 × 10−1 |
| TACTTT | 5.7 | −0.204 | 8.4 × 10−1 |
| GAGTTT | 8.6 | 0.299 | 7.6 × 10−1 |
| GACTTT | 51.7 | 1.629 | 9.7 × 10−2 |
| c: haplotype block 3: antisaccade eye movement | |||
| CAACCGGG | 9.0 | −2.911 | 4.0 × 10−3 # |
| ACGTCGGG | 3.7 | −1.241 | 2.1 × 10−1 |
| CAACTGGG | 16.3 | −0.131 | 9.0 × 10−1 |
| ACGTCAGA | 20.5 | 0.193 | 8.5 × 10−1 |
| ACGTCATA | 2.3 | 0.211 | 8.3 × 10−1 |
| ACGCCGGG | 23.0 | 0.636 | 5.3 × 10−1 |
| ACGTCAGG | 23.5 | 1.247 | 2.1 × 10−1 |
| CCGCCGGG | 1.7 | 1.822 | 6.8 × 10−1 |
| d: haplotype block 3: mRNA expression | |||
| CAACCGGG | 7.1 | −2.068 | 3.5 × 10−2 |
| CCGCCGGG | 2.3 | −1.281 | 2.1 × 10−1 |
| ACGTCATA | 2.6 | −0.685 | 5.0 × 10−1 |
| ACGCCGGG | 26.6 | −0.554 | 5.8 × 10−1 |
| ACGTCAGA | 21.2 | 0.608 | 5.4 × 10−1 |
| ACGTCGGG | 4.2 | 0.856 | 4.0 × 10−1 |
| CAACTGGG | 15.4 | 0.864 | 4.0 × 10−1 |
| ACGTCAGG | 20.5 | 0.921 | 3.6 × 10−1 |
| e: haplotype block 4: P50 T/C Ratio | |||
| TAC | 36.6 | −2.039 | 4.6 × 10−2 |
| CAC | 17.8 | 0.129 | 9.0 × 10−1 |
| CGC | 19.7 | 0.767 | 4.5 × 10−1 |
| CAT | 0.8 | 0.830 | 4.2 × 10−1 |
| TAT | 24.7 | 1.546 | 1.2 × 10−1 |
| f: haplotype block 4: mRNA expression | |||
| TAC | 35.5 | −1.773 | 7.4 × 10−2 |
| TGC | 0.6 | 0.179 | 8.0 × 10−1 |
| CGC | 26.3 | 0.490 | 6.3 × 10−1 |
| TAT | 23.6 | 0.695 | 4.9 × 10−1 |
| CAC | 13.9 | 0.912 | 3.7 × 10−1 |
a, b Association analysis of haplotype block 2 with antisaccade task performance (correct responses) and mRNA expression of CRYBB2 from lymphocytes. c, d Association analysis of haplotype block 3 with antisaccade task performance (correct responses) and mRNA expression of CRYBB2 from lymphocytes. e, f Association analysis of haplotype block 4 with sensorimotor gating measured as P50 ratio and mRNA expression of CRYBB2 from lymphocytes.
Nominal significant p-values (p < 0.05) are marked bold, #p-value passes Bonferroni correction for number of endophenotype-specific analyses performed and number of haploblocks.