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. 2020 Apr 21;10:6751. doi: 10.1038/s41598-020-63290-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Increased number of GFRα1+ spermatogonia in Sox3^−/Y testis. (A) Frequency plot showing more GFRα1+ cells per tubule in Sox3 null testis cross-sections (12.3+/− 0.28) compared to WT (6.2+/−0.19), Ρ < 0.0001. (B) Cell counts of the different spermatogonia cell identities as marked by SOX3/GFP and or GFRα1 staining. IF of WT testis cross sections at P7 (C), and Sox3 null testis sections (D), staining for SOX3 (red) and GFRα1 (green). Minimum 10 fields of view per counted section, 3 sections per testis, n = 3 for each genotype, not significant (ns), Ρ < 0.05 (*), Ρ < 0.0001(****) as determined by Mann-Whitney test. Data represented as mean±s.d., scale bar is 50μm (C,D).