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. 2020 Apr 21;10:6751. doi: 10.1038/s41598-020-63290-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Ngn3 is a direct SOX3 target gene in spermatogonia. UCSC Genome Browser view of published SOX3 ChIP-seq data⁴² from neural progenitor cells showing a SOX3 binding site within the upstream promoter region of Ngn3 (A). ChIP-PCR for SOX3 in P7 testis (B), demonstrating SOX3 binding upstream of the Ngn3 promoter (Ngn3), Ρ < 0.05 (*), Ρ < 0.01 (**) as determined by t-test, data represented as mean±s.d. –ve control represents a site within Notch1 known not to bind SOX3, +ve control represents a site within intron 2 of Dbx1 previously validated as a binding site of SOX3⁴¹.