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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: Trends Biochem Sci. 2020 Feb 17;45(5):397–410. doi: 10.1016/j.tibs.2020.01.006

Figure 4. The putative sterol transport tunnel in PTCH1.

Figure 4

(A) and (B) The putative sterol tunnel in PTCH1. A tunnel across PTCH1 was predicted based on protein structure. PTCH1 may transport sterols through this tunnel. Nanobody Tl23 squeezes the tunnel and may inhibit the activity of PTCH1. The tunnel is indicated in gray and the two gates in the transmembrane domain are indicated. Tl23 (green) binding site is colored in magenta. (C) Model of PTCH1-mediated sterol transport. PTCH1 may transport the sterol from the inner leaflet to outer leaflet of the cell membrane.