Table 2.
Differentially regulated transcripts in high impulsive rats from the outbred base and F6 inbred populations.
| Gene symbol | Gene description | False Discovery Rate (associated fold change: high / low impulsivity) | ||
|---|---|---|---|---|
| NacC | NacS | ILC | ||
| Up-regulated transcripts in high impulsive rats from the outbred base population | ||||
| Alg8 | Asparagine-linked glycosylation 8, alpha-1,3-glucosyltransferase homolog (S, cerevisiae) | 85.4% (1.05) | 6.5% (1.20) | — |
| Atg16l2 | ATG16 autophagy related 16-like 2 (S. cerevisiae) | 77.3% (1.03) | 1.0% (1.23) | — |
| Dkk3 | Dickkopf homolog 3 (Xenopus laevis) | 25.0% (1.08) | <0.1% (1.41) | — |
| Fam160a2 | Family with sequence similarity 160, member A2 | 79.6% (1.05) | 0.1% (1.31) | — |
| Inppl1 | Inositol polyphosphate phosphatase-like 1 | 92.4% (0.99) | 8.2% (1.18) | — |
| Mesdc1 | Mesoderm development candidate 1 | 18.7% (1.11) | 8.8% (1.17) | — |
| Mesp1 | Mesoderm posterior protein 1 | 33.2% (1.08) | 0.6% (1.24) | — |
| Nmb | Neuromedin B | 79.4% (0.69) | 0.5% (1.10)* | — |
| Nucb2 | Nucleobindin 2 | 36.4% (1.07) | 0.7% (1.23) | — |
| RGD1561459 | Similar to RIKEN cDNA 1810020D17 | 100.0% (1.00) | 9.6% (1.19) | — |
| Rlbp1 | Retinaldehyde binding protein 1 | 100.0% (1.03) | 1.2% (1.24) | — |
| Sv2b | Synaptic vesicle glycoprotein 2B | 4.3% (1.12) | 82.6% (0.80) | — |
| Wee1 | Wee 1 homolog (S. pombe) | 100.0% (1.00) | 9.4% (1.18) | — |
| Down-regulated transcripts in high impulsive rats from the outbred base population | ||||
| Clpb | ClpB caseinolytic peptidase B homolog (E, coli) | 98.6% (0.97) | 0.4% (0.71) | — |
| Far1 | Fatty acyl CoA reductase 1 | 100.0% (0.97) | <0.1% (0.58) | — |
| Folh1 | Folate hydrolase 1 | — | 0.1% (0.71) | — |
| Grm5 | Metabotropic glutamate receptor 5 | — | 0.1% (0.67) | — |
| Hbb | Hemoglobin, beta | 8.9% (0.89) | 2.3% (0.78)* | — |
| Mesdc2 | Mesoderm development candidate 2 | 84.6% (0.94) | 5.4% (0.80) | — |
| Nmb | Neuromedin B | <0.1% (0.69) | 26.3% (1.10) | — |
| Olfml1 | Olfactomedin-like 1 | 100.0% (0.97) | 7.4% (0.82) | — |
| Pak1 | p21 protein (Cdc42/Rac)-activated kinase 1 | 100.0% (0.99) | 0.4% (0.72) | — |
| Pde3b | Phosphodiesterase 3B, cGMP-inhibited | 2.6% (0.92) | 27.1% (0.96) | — |
| Picalm | Phosphatidylinositol binding clathrin assembly protein | 8.9% (0.90) | <0.1% (0.62) | — |
| Rnf141 | RING finger protein 141 | — | <0.1% (0.54) | — |
| Serpinh1 | Serine (or cysteine) peptidase inhibitor, clade H, member 1 | 11.6% (0.92) | 0.5% (0.74) | — |
| Spcs2 | Signal peptidase complex subunit 2 homolog (S, cerevisiae) | 67.1% (0.94) | 1.6% (0.75) | — |
| Sv2b | Synaptic vesicle glycoprotein 2b | 100.0% (1.12) | 1.2% (0.80) | — |
| Usp47 | Ubiquitin specific peptidase 47 | 100.0% (0.98) | 3.5% (0.79) | — |
| Up-regulated transcripts in high impulsive rats from the inbred F6 population | ||||
| Nmb | Neuromedin-B | <0.1% (1.46) | <0.1% (1.81)* | 11.9% (1.39) |
| Nrip3 | Nuclear receptor interacting protein 3 | 8.0% (1.21) | 63.7% (1.09) | 35.9% (1.10) |
| Pde3b | Phosphodiesterase 3B, cGMP-inhibited | 3.8% (1.25) | 33.5% (1.14) | 15.9% (1.19) |
| Sv2b | Synaptic vesicle glycoprotein 2B | 36.9% (1.01) | 1.9% (1.24) | 5.1% (1.21) |
| Thrsp | Thyroid hormone responsive | 100.0% (0.84) | 8.2% (1.21) | 88.2% (1.03) |
| Tm6sf1 | Transmembrane 6 superfamily member 1 | 2.2% (1.24) | 100.0% (1.00) | 100.0% (1.01) |
| Down-regulated transcripts in high impulsive rats from the inbred F6 population | ||||
| Cpeb1 | cytoplasmic polyadenylation element binding protein 1 | 38.1% (0.85) | — | 6.0% (0.87) |
| Dkk3 | dickkopf homolog 3 | 4.79% (0.85) | 100.0% (1.11) | 99.6% (1.11) |
| Hbb | hemoglobin, beta | 1.0% (0.84) | 6.3% (0.85)* | 1.3% (0.95) |
| LOC689064 | beta-globin | 0.9% (0.86) | 11.8% (0.85) | 0.5% (0.95) |
| Ppfibp2 | Protein tyrosine phosphatase, receptor type, F interacting protein, binding protein 2 | 100.0% (1.04) | 100.0% (0.97) | 5.8% (0.77) |
| Prc1 | protein regulator of cytokinesis 1 | 5.9% (0.83) | — | — |
| Thrsp | thyroid hormone responsive | 7.5% (0.84) | 100.0% (1.20) | 100.0% (1.03) |
False discovery rates and associated fold change for differentially-expressed genes in the identified linkage region in the nucleus accumbens core (NAcC), nucleus accumbens shell (NAcS) and infralimbic cortex (ILC). Bold denotes significantly-altered expression (10% FDR), - denotes not assessed, *differentially expressed in both base and F6 population.