TABLE 2.

Summary of known HSP60 inhibitors^a.

Class	Inhibitor	Effect	References
	Mizoribine	Binds to the HSP60 ATPase domain and inhibits the chaperoning activity of Hsp60–Hsp10 complex	Itoh et al., 1999; Tanabe et al., 2012
Natural products	Epolactaene	Inhibits the chaperone activity of HSP60 with yet unclear mechanism	Nagumo et al., 2005; Meng et al., 2018
	ETB (tert-butyl ester of epolactaene)	Interacts with Cys442 of HSP60 leading to potential allosteric modulation of the ATP binding pocket	Nagumo et al., 2005
	Myrtucommulone A (MC)	Interacts directly with HSP60 leading to aggregation and misfolding of cancer related proteins	Wiechmann et al., 2017
	Stephacidin B	Performs anticancer activities	Qian-Cutrone et al., 2002; Wulff et al., 2007
	Avrainvillamide	Anticancer activities	Fenical et al., 2000
Synthetic compounds	O-carboranylphenoxyacetanilide	Binds to HSP60 and inhibits the hypoxia-inducible factor (HIF) activation	Ban et al., 2010
	Gold (III) porphyrin complexes such as A prototype gold (III) complex [Au(TPP)Cl] (10)	Despite its poorly understood mechanisms, it suppresses HSP60 and performs significant anticancer activities	Lease et al., 2013; Teo et al., 2014; Hu et al., 2016

^aNakamura and Minegishi, 2013; Meng et al., 2018.