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. 2020 Apr 15;8:269. doi: 10.3389/fbioe.2020.00269

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Copyright © 2020 Dorrello and Vunjak-Novakovic.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of XC platform on porcine lung injury. (A) Schematic representation of XC platform. (B,C) Ischemic/reperfusion injury. (B) Porcine lungs mounted on XC platform showed macroscopic (i), radiographic (ii), and thermographic (iii) improvement after 18 h of cold ischemia. (C) Improvement of lung compliance of ischemic lungs on XC analyzed by pressure-volume loops (PV). Images reproduced with permission from O’Neill et al. (2017). (D,E) Gastric aspiration lung injury. (D) Porcine lungs mounted on 36 h XC platform showed macroscopic (i), radiographic (ii), and thermographic (iii) recovery after 6 h of porcine gastric contents injury. (E) Significant improvements of PV loops and dynamic compliance of injured lungs were observed throughout 36 h of XC support. Images reproduced with permission from Guenthart et al. (2019b).