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. 2020 Apr 15;11:649. doi: 10.3389/fmicb.2020.00649

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Copyright © 2020 Bichat, Plassais, Ambroise and Mariadassou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Example wokflow of hFDR. Nodes are numbered from 1 to 12 and the corresponding hypothesis are labeled H₁ to H₁₂. hFDR first tests and rejects H₁ and H₂. It then tests the family (H₃, H₄), as children of H₁, and rejects H₄ but not H₃. None of H₇, H₈ and H₉ are tested as their parent H₃ is not rejected. H₁₀ is tested and rejected. It proceeds similarly in the tree rooted at node 2. In this example, there are 3 leaf-level discoveries (H₁₀, H₁₁ and H₁₂) and 5 families were tested. Then the a posteriori global FDR for leaves is 1.44 × α × 2.