Table 3.
Downregulated titin phosphosites (log2 ratio KO/WT <−0.37).
| Position within titin | UniProt identifyer | Log2 ratio (KO/WT) | –Log 10 p-value KO/WT | Charge | Multiplicity | Localization probability | Classification of phosphosite | Sequence window |
|---|---|---|---|---|---|---|---|---|
| S23560 | A2ASS6 | −0.372779 | 0 | 3 | 1 | 0.692852 | Class 2 | PGPPGNPRVLDTSRSSISIAWNKPIYDGGSE |
| S18225 | A2ASS6 | −0.376743 | 0.548646 | 2 | 1 | 0.5 | Class 2 | PPGPPFPKVTDWTKSSVDLEWSPPLKDGGSK |
| S30484 | A2ASS6 | −0.380153 | 0 | 2 | 1 | 0.999969 | Class 1 | TWKLEEMRLKETDRMSIATTKDRTTLTVKDS |
| S34451 | A2ASS6 | −0.384564 | 0.573934 | 2 | 1 | 0.999956 | Class 1 | TLTVQKARVIEKAVTSPPRVKSPEPRVKSPE |
| S33933 | A2ASS6 | −0.390718 | 0.578927 | 2 | 1 | 0.999999 | Class 1 | SRSPPRFELSSLRYSSPPAHVKVEDRRRDFR |
| S34808 | A2ASS6 | −0.390976 | 0.349281 | 2 | 1 | 1 | Class 1 | IAEEVKRSAAASLEKSIVHEEVTKTSQASEE |
| S26062 | A2ASS6 | −0.391391 | 0 | 3 | 1 | 0.992938 | Class 1 | KWSVVAESKVCNAVVSGLSSGQEYQFRVKAY |
| S21726 | A2ASS6 | −0.391912 | 0.585051 | 2 | 1 | 0.999998 | Class 1 | FLTEENKWQRVMKSLSLQYSTKDLKEGKEYT |
| T27227 | A2ASS6 | −0.392365 | 0 | 3 | 1 | 0.598045 | Class 2 | QATVAWKKDGQVLRETTRVNVASSKTVTTLS |
| S34476 | A2ASS6 | −0.399261 | 0.538309 | 2 | 1 | 1 | Class 1 | RVKSPETVKSPKRVKSPEPVTSHPKAVSPTE |
| S28859 | A2ASS6 | −0.403171 | 0.471662 | 2 | 1 | 0.990318 | Class 1 | EPVVAKNAFVTPGPPSIPEVTKITKNSMTVV |
| T4070 | A2ASS6-3 | −0.408659 | 0.331878 | 3 | 1 | 0.998519 | Class 1 | RELLSFPVEIQITAATPTPEQNKECRELFEL |
| S22271 | A2ASS6 | −0.42308 | 0 | 3 | 1 | 0.944504 | Class 1 | VSVLDVPGPPGPIEISNVSAEKATLTWTPPL |
| S1196 | A2ASS6 | −0.429651 | 0.300969 | 3 | 1 | 0.887311 | Class 1 | ALVKTQQEMLYQTQMSTFIQEPKVGEIAPGF |
| S29764 | A2ASS6 | −0.433024 | 0.621301 | 2 | 1 | 0.999999 | Class 1 | FGPEYFDGLVIKSGDSLRIKALVQGRPVPRV |
| S26804 | A2ASS6 | −0.433475 | 0 | 3 | 1 | 0.524536 | Class 2 | LYPPGPPSNPKVTDTSRSSVSLAWNKPIYDG |
| S22184 | A2ASS6 | −0.435231 | 0 | 2 | 1 | 0.999983 | Class 1 | LDPTIKDGLTVKAGDSIVLSAISILGKPLPK |
| S28389 | A2ASS6 | −0.440064 | 0 | 2 | 1 | 0.999873 | Class 1 | ESVTLKWEPPKYDGGSHVTNYIVLKRETSTA |
| S19152 | A2ASS6 | −0.442809 | 0 | 2 | 1 | 0.686958 | Class 2 | RKDVATAQWSPLSTTSKKKSHMAKHLTEGNQ |
| S34292 | A2ASS6 | −0.458658 | 1.00349 | 2 | 1 | 0.997471 | Class 1 | LTKTEAYAVSSFKRTSELEAASSVREVKSQM |
| S848 | A2ASS6 | −0.472572 | 0.731925 | 2 | 1 | 0.999987 | Class 1 | ASIAGSAIATLQKELSATSSTQKITKSVKAP |
| S19518 | A2ASS6 | −0.479462 | 0 | 3 | 1 | 0.999999 | Class 1 | DITENAATVSWTLPKSDGGSPITGYYVERRE |
| T4827 | A2ASS6-3 | −0.480703 | 0 | 3 | 2 | 0.682593 | Class 2 | VRDTKHKAQLVQSDSTTSMEVEEVTFNTVYE |
| S16544 | A2ASS6 | −0.489219 | 1.48858 | 3 | 1 | 0.993809 | Class 1 | AEEEEPFSLPLTERLSINNSKQGESQLRIRD |
| S29489 | A2ASS6 | −0.490109 | 0.49045 | 2 | 1 | 0.999929 | Class 1 | GGGEITCYSIEKREASQTNWKMVCSSVARTT |
| S35097 | A2ASS6 | −0.491363 | 0.979128 | 3 | 1 | 0.972789 | Class 1 | ESFVEMSSSSFMGKSSMTQLESSTSRMLKAG |
| S29997 | A2ASS6 | −0.496859 | 0.246525 | 3 | 1 | 0.999978 | Class 1 | KKSTRWVKVISKRPISETRFKVTGLVEGNEY |
| S23358 | A2ASS6 | −0.498498 | 0.499119 | 3 | 1 | 0.855607 | Class 1 | RPGPPEGPLAVSDVTSEKCVLSWLPPLDDGG |
| S262 | A2ASS6 | −0.501588 | 0 | 2 | 1 | 1 | Class 1 | QLPHKTPPRIPPKPKSRSPTPPSIAAKAQLA |
| S30452 | A2ASS6 | −0.513035 | 0.782215 | 2 | 1 | 0.968235 | Class 1 | DLTGITNQLITCKAGSTFTIDVPISGRPAPK |
| S16548 | A2ASS6 | −0.515562 | 0.899345 | 3 | 1 | 0.999832 | Class 1 | EPFSLPLTERLSINNSKQGESQLRIRDSLRP |
| S24061 | A2ASS6 | −0.515855 | 0.613502 | 2 | 1 | 0.97456 | Class 1 | SVTLSWEPPKYDGGSSINNYIVEKRDTSTTA |
| T23053 | A2ASS6 | −0.515985 | 0.758139 | 2 | 1 | 0.999999 | Class 1 | SVVANYPFKVPGPPGTPQVTAVTKDSMTISW |
| S1120 | A2ASS6 | −0.516292 | 0.722335 | 2 | 1 | 1 | Class 1 | CQIGGNPKPHVYWKKSGVPLTTGYRYKVSYN |
| S21895 | A2ASS6 | −0.522994 | 0.473161 | 2 | 1 | 1 | Class 1 | EAMTLKWGPPKDDGGSEITNYVLEKRDSVNN |
| S34756 | A2ASS6 | −0.525721 | 0.586585 | 2 | 1 | 1 | Class 1 | VSTQKTSEVTSQKKASAQEEISQKALTSEEI |
| S21162 | A2ASS6 | −0.54349 | 0.319895 | 2 | 1 | 0.836052 | Class 1 | VNRKDSGDYTITAENSSGSKSATIKLKVLDK |
| S34778 | A2ASS6 | −0.543969 | 0.489795 | 2 | 1 | 0.999964 | Class 1 | QKALTSEEIKMSEVKSHETLAIKEEASKVLI |
| T22513 | A2ASS6 | −0.551522 | 0 | 3 | 1 | 0.958776 | Class 1 | VEHQKVGDDAWIKDTTGTALRITQFVVPDLQ |
| T24135 | A2ASS6 | −0.561529 | 0.975063 | 2 | 1 | 1 | Class 1 | PVVAQYPFKVPGPPGTPFVTLASKDSMEVQW |
| T23980 | A2ASS6 | −0.573932 | 0.604136 | 3 | 1 | 0.631224 | Class 2 | PPAVTWHKDDIPLKQTTRVNAESTENNSLLT |
| S21730 | A2ASS6 | −0.574432 | 0.464884 | 2 | 1 | 0.798102 | Class 1 | ENKWQRVMKSLSLQYSTKDLKEGKEYTFRVS |
| S23609 | A2ASS6 | −0.587423 | 0 | 2 | 1 | 0.995346 | Class 1 | VTPPAGLKATSYTITSLIENQEYKIRIYAMN |
| S4650 | A2ASS6-3 | −0.606701 | 0 | 3 | 1 | 0.981316 | Class 1 | ALFQTPSADVEEANVSETGASVENGDKTFIS |
| T25062 | A2ASS6 | −0.625343 | 0 | 3 | 1 | 0.499999 | Class 2 | KPSISWTKDGMPLKQTTRINVTDSLDLTTLS |
| T25063 | A2ASS6 | −0.625343 | 0 | 3 | 1 | 0.499999 | Class 2 | PSISWTKDGMPLKQTTRINVTDSLDLTTLSI |
| S16620 | A2ASS6 | −0.62959 | 0.594816 | 3 | 1 | 0.999999 | Class 1 | DSVLCKWEPPLDDGGSEIINYTLEKKDKTKP |
| S25817 | A2ASS6 | −0.632049 | 0.301091 | 2 | 1 | 1 | Class 1 | VKPEDKLEAPELDLDSELRKGIVVRAGGSAR |
| S34207 | A2ASS6 | −0.63678 | 0 | 2 | 1 | 0.992242 | Class 1 | AEVKWYHNGVELQESSKIHYTNTSGVLTLEI |
| S20215 | A2ASS6 | −0.644393 | 0.578427 | 2 | 1 | 0.989323 | Class 1 | EMTVVWNAPEYDGGKSITGYYLEKKEKHAVR |
| T30560 | A2ASS6 | −0.645399 | 0.70904 | 2 | 1 | 1 | Class 1 | ESCVLSWTEPKDDGGTEITNYIVEKRESGTT |
| T9146 | A2ASS6 | −0.650309 | 0.429695 | 3 | 1 | 0.616703 | Class 2 | KERLIPPSFTKKLSETVEETEGNSFKLEGRV |
| S33880 | A2ASS6 | −0.659036 | 1.33033 | 3 | 1 | 1 | Class 1 | DLYYYRRRRRSLGDMSDEELLLPIDDYLAMK |
| S21163 | A2ASS6 | −0.662774 | 0 | 2 | 1 | 0.555375 | Class 2 | NRKDSGDYTITAENSSGSKSATIKLKVLDKP |
| S32940 | A2ASS6 | −0.669661 | 0.567747 | 3 | 1 | 0.991067 | Class 1 | DSVNLTWTEPASDGGSKVTNYIVEKCATTAE |
| T27381 | A2ASS6 | −0.676248 | 0.40741 | 2 | 1 | 0.987482 | Class 1 | AVVAEYPFSPPGPPGTPKVVHATKSTMVVSW |
| S22466 | A2ASS6 | −0.68697 | 0.37929 | 3 | 1 | 0.971535 | Class 1 | NPVLMKDVAYPPGPPSNAHVTDTTKKSASLA |
| S15406 | A2ASS6 | −0.717398 | 0.426932 | 2 | 1 | 1 | Class 1 | NSIFLTWDPPKNDGGSRIKGYIVEKCPRGSD |
| S24060 | A2ASS6 | −0.726107 | 0.454637 | 2 | 1 | 0.965865 | Class 1 | DSVTLSWEPPKYDGGSSINNYIVEKRDTSTT |
| S17508 | A2ASS6 | −0.743691 | 0.827831 | 3 | 1 | 0.854636 | Class 1 | PPGPPSCPEVKDKTKSSISLAWKPPAKDGGS |
| S22646 | A2ASS6 | −0.746741 | 0 | 3 | 1 | 0.999997 | Class 1 | TGKFVMTIENPAGKKSGFVNVRVLDTPGPVL |
| Y21461 | A2ASS6 | −0.750766 | 0 | 2 | 1 | 0.997236 | Class 1 | NTEYQFRVYAVNKIGYSDPSDVPDKHCPKDI |
| S34464 | A2ASS6 | −0.758656 | 0.611225 | 2 | 1 | 1 | Class 1 | VTSPPRVKSPEPRVKSPETVKSPKRVKSPEP |
| S19128 | A2ASS6 | −0.761375 | 0.661405 | 3 | 1 | 1 | Class 1 | DSCYLTWKEPLDDGGSVVTNYVVERKDVATA |
| S17509 | A2ASS6 | −0.765849 | 0.574468 | 2 | 1 | 0.499998 | Class 2 | PGPPSCPEVKDKTKSSISLAWKPPAKDGGSP |
| S34009 | A2ASS6 | −0.77042 | 0.791858 | 2 | 1 | 1 | Class 1 | LLRPVTTTQRLSEYKSELDYMSKEEKSKKKS |
| S30820 | A2ASS6 | −0.787034 | 0 | 3 | 1 | 0.779125 | Class 1 | VLAKNAAGVISKGSESTGPVTCRDEYAPPKA |
| S34653 | A2ASS6 | −0.82199 | 0.752192 | 2 | 1 | 0.95726 | Class 1 | SSKPVIVTGLRDTTVSSDSVAKFTIKVTGEP |
| S32936 | A2ASS6 | −0.824822 | 0 | 3 | 1 | 0.909829 | Class 1 | DVSRDSVNLTWTEPASDGGSKVTNYIVEKCA |
| T16910 | A2ASS6 | −0.831267 | 0.77835 | 3 | 1 | 1 | Class 1 | LDVSVKGGIQIMAGKTLRIPAEVTGRPVPTK |
| S15236 | A2ASS6 | −0.836399 | 0.546251 | 3 | 1 | 0.997816 | Class 1 | DQVLEEGDRVKMKTISAYAELVISPSERTDK |
| S21637 | A2ASS6 | −0.851016 | 0.751694 | 2 | 1 | 0.999673 | Class 1 | WSTVTTECSKTSFRVSNLEEGKSYFFRVFAE |
| T30103 | A2ASS6 | −0.851493 | 0 | 3 | 1 | 0.499919 | Class 2 | DWHKVNTEPCVKTRYTVTDLQAGEEYKFRVS |
| S32230 | A2ASS6 | −0.864269 | 0.82444 | 2 | 1 | 0.991873 | Class 1 | DPFDKPSQPGELEILSISKDSVTLQWEKPEC |
| S34005 | A2ASS6 | −0.876525 | 0 | 3 | 1 | 0.999798 | Class 1 | EEEELLRPVTTTQRLSEYKSELDYMSKEEKS |
| S18731 | A2ASS6 | −0.87685 | 0.25695 | 3 | 1 | 0.995523 | Class 1 | EYMVISWKPPLDDGGSEITNYIIEKKELGKD |
| S4248 | A2ASS6-3 | −0.893375 | 0 | 4 | 1 | 0.967119 | Class 1 | VQGEPVRTHFYDHTVSPFAAQSNIKEYTIRE |
| T30453 | A2ASS6 | −0.895531 | 0.674399 | 3 | 1 | 0.861201 | Class 1 | LTGITNQLITCKAGSTFTIDVPISGRPAPKV |
| S1805 | A2ASS6 | −0.895653 | 0.717555 | 2 | 1 | 1 | Class 1 | GTDHTSATLIVKDEKSLVEESQLPDGKKGLQ |
| S15266 | A2ASS6 | −0.907094 | 0 | 2 | 1 | 0.977731 | Class 1 | KGIYTLTLENPVKSISGEINVNVIAPPSAPK |
| S25399 | A2ASS6 | −0.923229 | 0.531448 | 2 | 1 | 0.967678 | Class 1 | VIAKNAAGAISKPSDSTGPITAKDEVELPRI |
| S27960 | A2ASS6 | −0.925189 | 0.489628 | 2 | 1 | 0.834475 | Class 1 | RVRSLNKMGASDPSDSSDPQVAKEREEEPVF |
| S3286 | A2ASS6 | −0.938293 | 0.866542 | 2 | 1 | 0.851679 | Class 1 | RPQPKISWYKEEQLLSTGFKCKFLHDGQEYT |
| T22529 | A2ASS6 | −0.943427 | 0.67514 | 2 | 1 | 1 | Class 1 | GTALRITQFVVPDLQTKEKYNFRISAINDAG |
| S4720 | A2ASS6-3 | −0.959846 | 0 | 3 | 1 | 0.9499 | Class 1 | PRGAVHGAEVPHRRLSLSQDLPFLMTGEQQD |
| S35060 | A2ASS6 | −0.967557 | 0 | 2 | 1 | 0.845469 | Class 1 | SASKQEASFSSFSSSSASSMTEMKFASMSAQ |
| Y20757 | A2ASS6 | −0.96841 | 0.688841 | 2 | 1 | 0.999745 | Class 1 | SSVLIIKDVTRKDSGYYSLTAENSSGSDTQK |
| S25797 | A2ASS6 | −0.975471 | 0.492227 | 2 | 1 | 0.999986 | Class 1 | IRVCALNKVGLGEAASVPGTVKPEDKLEAPE |
| S23925 | A2ASS6 | −1.00025 | 0.887458 | 3 | 1 | 0.999906 | Class 1 | VSAQNEKGISDPRQLSVPVIAKDLVIPPAFK |
| S25613 | A2ASS6 | −1.02282 | 0.946511 | 2 | 1 | 1 | Class 1 | PVLMKNPFVLPGPPKSLEVTNIAKDSMTVCW |
| S29299 | A2ASS6 | −1.03903 | 0.614927 | 2 | 1 | 0.999999 | Class 1 | TDYLVERKGKGEQAWSHAGISKTCEIEIGQL |
| Y20182 | A2ASS6 | −1.04142 | 0.707871 | 3 | 1 | 1 | Class 1 | TGPPTESKPVIAKTKYDRPGRPDPPEVTKVS |
| S35104 | A2ASS6 | −1.0585 | 0 | 2 | 1 | 0.746582 | Class 2 | SSSFMGKSSMTQLESSTSRMLKAGGRGIPPK |
| S15616 | A2ASS6 | −1.06363 | 0.707178 | 2 | 1 | 0.999998 | Class 1 | GSKITNYVVERKATDSDVWHKLSSTVKDTNF |
| S20732 | A2ASS6 | −1.08258 | 0.581344 | 2 | 1 | 0.997277 | Class 1 | PICKWKKGDDEVVTSSHLAIHKADGSSVLII |
| T16946 | A2ASS6 | −1.0848 | 0 | 2 | 1 | 1 | Class 1 | EGELDKERVIIENVGTKSELIIKNALRKDHG |
| S24436 | A2ASS6 | −1.0957 | 0.769352 | 3 | 1 | 0.997797 | Class 1 | KVLDRPGPPEGPVAISGVTAEKCTLAWKPPL |
| S19776 | A2ASS6 | −1.13133 | 0 | 4 | 1 | 0.570984 | Class 2 | VRADHGKYIISAKNSSGHAQGSAIVNVLDRP |
| T30100 | A2ASS6 | −1.14081 | 0.86237 | 2 | 1 | 0.999845 | Class 1 | DLGDWHKVNTEPCVKTRYTVTDLQAGEEYKF |
| S28970 | A2ASS6 | −1.14229 | 0.390143 | 2 | 1 | 0.848484 | Class 1 | PPGPPAKIRIADSTKSSITLGWSKPVYDGGS |
| S23728 | A2ASS6 | −1.15678 | 0 | 2 | 1 | 0.680757 | Class 2 | FDSGKYILTVENSSGSKSAFVNVRVLDTPGP |
| S23604 | A2ASS6 | −1.18392 | 0 | 2 | 1 | 0.760984 | Class 1 | DEWQVVTPPAGLKATSYTITSLIENQEYKIR |
| T22805 | A2ASS6 | −1.18392 | 0.725798 | 2 | 1 | 0.948992 | Class 1 | IEAQRKGSDQWTHISTVKGLECVVRNLTEGE |
| S25730 | A2ASS6 | −1.2141 | 1.02176 | 2 | 1 | 0.999999 | Class 1 | AHVVDTTKNSITLAWSKPIYDGGSEILGYVV |
| S24155 | A2ASS6 | −1.21435 | 0.495954 | 3 | 1 | 0.938049 | Class 1 | LASKDSMEVQWHEPVSDGGSKVIGYHLERKE |
| T23603 | A2ASS6 | −1.22489 | 0.565233 | 2 | 1 | 0.891141 | Class 1 | EDEWQVVTPPAGLKATSYTITSLIENQEYKI |
| S29402 | A2ASS6 | −1.22605 | 1.20053 | 2 | 1 | 1 | Class 1 | LKDGLPLKESEYVRFSKTENKITLSIKNSKK |
| T25518 | A2ASS6 | −1.23095 | 0.735191 | 3 | 1 | 0.981598 | Class 1 | KVLDRPGPPEGPVQVTGVTAEKCTLAWSPPL |
| T19879 | A2ASS6 | −1.23865 | 1.098 | 3 | 1 | 1 | Class 1 | CAENKVGVGPTIETKTPILAINPIDRPGEPE |
| Y29398 | A2ASS6 | −1.26528 | 0.758789 | 2 | 1 | 1 | Class 1 | SISWLKDGLPLKESEYVRFSKTENKITLSIK |
| S32140 | A2ASS6 | −1.27419 | 0.799964 | 2 | 1 | 0.998818 | Class 1 | PEVLDVTKSSVSLSWSRPKDDGGSRVTGYYI |
| S28985 | A2ASS6 | −1.28346 | 0 | 2 | 1 | 0.999999 | Class 1 | SSITLGWSKPVYDGGSDVTGYVVEMKQGDEE |
| S35029 | A2ASS6 | −1.33441 | 0 | 3 | 1 | 0.960754 | Class 1 | PLVEEPPREVVLKTSSDVSLHGSVSSQSVQM |
| S34457 | A2ASS6 | −1.40297 | 0 | 2 | 2 | 1 | Class 1 | ARVIEKAVTSPPRVKSPEPRVKSPETVKSPK |
| S35096 | A2ASS6 | −1.44254 | 0.872837 | 2 | 1 | 0.869587 | Class 1 | QESFVEMSSSSFMGKSSMTQLESSTSRMLKA |
| T22515 | A2ASS6 | −1.45339 | 0 | 3 | 1 | 0.998937 | Class 1 | HQKVGDDAWIKDTTGTALRITQFVVPDLQTK |
| S25026 | A2ASS6 | −1.48484 | 0.743171 | 3 | 1 | 0.949735 | Class 1 | IAKDLVIEPDVRPAFSSYSVQVGQDLKIEVP |
| S21724 | A2ASS6 | −1.49957 | 0 | 2 | 1 | 0.965611 | Class 1 | VDFLTEENKWQRVMKSLSLQYSTKDLKEGKE |
| S27185 | A2ASS6 | −1.55785 | 0.714422 | 2 | 1 | 1 | Class 1 | QLGVPVIAKDIEIKPSVELPFNTFNVKANDQ |
| S34009 | A2ASS6 | −2.60171 | 0 | 2 | 2 | 1 | Class 1 | LLRPVTTTQRLSEYKSELDYMSKEEKSKKKS |
A-band.