Table 5.
Unchanged titin phosphosites (−0.37 < log2 ratio KO/WT < 0.37).
| Position within titin | UniProt identifyer | Log2 ratio (KO/WT) | –Log 10 p-value KO/WT | Charge | Multiplicity | Localization probability | Classification of phosphosite | Sequence window |
|---|---|---|---|---|---|---|---|---|
| T26299 | A2ASS6 | −0.367305 | 0.338896 | 2 | 1 | 0.999988 | Class 1 | PVVVQYPFKEPGPPGTPFVTSISKDQMLVQW |
| S23354 | A2ASS6 | −0.359797 | 0 | 3 | 1 | 0.990613 | Class 1 | KVLDRPGPPEGPLAVSDVTSEKCVLSWLPPL |
| S34298 | A2ASS6 | −0.356955 | 0 | 3 | 1 | 0.609727 | Class 2 | YAVSSFKRTSELEAASSVREVKSQMTETRES |
| S34470 | A2ASS6 | −0.355278 | 0 | 2 | 1 | 1 | Class 1 | VKSPEPRVKSPETVKSPKRVKSPEPVTSHPK |
| S33875 | A2ASS6 | −0.353589 | 0.477593 | 3 | 2 | 1 | Class 1 | PSPDYDLYYYRRRRRSLGDMSDEELLLPIDD |
| S33880 | A2ASS6 | −0.353589 | 0.477593 | 3 | 2 | 1 | Class 1 | DLYYYRRRRRSLGDMSDEELLLPIDDYLAMK |
| S18562 | A2ASS6 | −0.350673 | 0.345871 | 2 | 1 | 1 | Class 1 | IGTEKFHKVTNDNLLSRKYTVKGLKEGDTYE |
| T22520 | A2ASS6 | −0.329784 | 0 | 3 | 1 | 0.995336 | Class 1 | DDAWIKDTTGTALRITQFVVPDLQTKEKYNF |
| S3977 | A2ASS6 | −0.319098 | 0.36361 | 2 | 1 | 0.840288 | Class 1 | CTEGKILMASADTLKSTGQDVALRTEEGKSL |
| S19146 | A2ASS6 | −0.318534 | 0.168528 | 2 | 1 | 0.995484 | Class 1 | TNYVVERKDVATAQWSPLSTTSKKKSHMAKH |
| T13665 | A2ASS6 | −0.316873 | 0.41921 | 2 | 1 | 1 | Class 1 | CEVSREPKTFRWLKGTQEITGDDRFELIKDG |
| S17098 | A2ASS6 | −0.305806 | 0.472482 | 2 | 1 | 0.933227 | Class 1 | PPTSPERLTYTERTKSTITLDWKEPRSDGGS |
| S24868 | A2ASS6 | −0.302999 | 0 | 2 | 1 | 0.998408 | Class 1 | KIKNYIVEKREATRKSYAAVVTNCHKNSWKI |
| S34470 | A2ASS6 | −0.302672 | 0.238728 | 2 | 2 | 1 | Class 1 | VKSPEPRVKSPETVKSPKRVKSPEPVTSHPK |
| S26806 | A2ASS6 | −0.301597 | 0 | 2 | 1 | 0.655766 | Class 2 | PPGPPSNPKVTDTSRSSVSLAWNKPIYDGGA |
| S18224 | A2ASS6 | −0.300622 | 0.391952 | 2 | 1 | 0.832005 | Class 1 | APPGPPFPKVTDWTKSSVDLEWSPPLKDGGS |
| S34464 | A2ASS6 | −0.2992 | 0.235518 | 2 | 2 | 1 | Class 1 | VTSPPRVKSPEPRVKSPETVKSPKRVKSPEP |
| S2080 | A2ASS6 | −0.298846 | 0.520376 | 2 | 1 | 1 | Class 1 | ITIPTFKPERIELSPSMEAPKIFERIQSQTV |
| S19448 | A2ASS6 | −0.273899 | 0 | 2 | 1 | 0.805061 | Class 1 | QDTRKGTWGVVSAGSSKLKLKVPHLQKGCEY |
| S13228 | A2ASS6 | −0.273069 | 0 | 2 | 1 | 0.993076 | Class 1 | DIPGEWKLKGELLRPSPTCEIKAEGGKRFLT |
| S27374 | A2ASS6 | −0.266139 | 0 | 3 | 1 | 0.820467 | Class 1 | SSYSESSAVVAEYPFSPPGPPGTPKVVHATK |
| S20517 | A2ASS6 | −0.265893 | 0 | 3 | 1 | 0.748614 | Class 2 | TSCHVSWAPPENDGGSQVTHYIVEKREAERK |
| S28343 | A2ASS6 | −0.263658 | 0 | 3 | 1 | 0.780076 | Class 1 | SVTTDAGRYEITAANSSGTTKTFINIIVLDR |
| S32318 | A2ASS6 | −0.262435 | 0.516907 | 2 | 1 | 0.999971 | Class 1 | SRPRRTAMSVKTKLTSGEAPGVRKEMADVTT |
| S3622 | A2ASS6-3 | −0.260512 | 0 | 3 | 1 | 0.962608 | Class 1 | VEEKGMVRTIHFRSASPVRRADYVYNDEWSE |
| Y21274 | A2ASS6 | −0.257528 | 0 | 3 | 1 | 1 | Class 1 | VGDPILTEPAIAKNPYDPPGRCDPPVISNIT |
| T22220 | A2ASS6 | −0.252516 | 0.8886 | 3 | 1 | 0.940036 | Class 1 | AGKDIRPSDIAQITSTPTSSMLTVKYATRKD |
| S22152 | A2ASS6 | −0.241103 | 0 | 2 | 1 | 0.761358 | Class 1 | IRAKNTAGAISAPSESTGTIICKDEYEAPTI |
| S20332 | A2ASS6 | −0.239112 | 1.58029 | 2 | 1 | 1 | Class 1 | IIGYVVEMRPKIADASPDEGWKRCNAAAQLI |
| S9201 | A2ASS6 | −0.230981 | 0 | 2 | 1 | 1 | Class 1 | IMFKNNALLLQVKRASMADAGLYTCKATNDA |
| S4098 | A2ASS6-3 | −0.229673 | 0 | 3 | 1 | 1 | Class 1 | FELEPEVTPRDQAIQSPKHKFIFSSDITNEP |
| S27782 | A2ASS6 | −0.229019 | 0 | 3 | 1 | 0.547507 | Class 2 | DPFTTPSPPTSLEITSVTKDSMTLCWSRPET |
| T27228 | A2ASS6 | −0.228542 | 0.209869 | 3 | 1 | 0.955571 | Class 1 | ATVAWKKDGQVLRETTRVNVASSKTVTTLSI |
| S20036 | A2ASS6 | −0.211545 | 0 | 2 | 1 | 0.999133 | Class 1 | EVAWTKDKDATDLTRSPRVKIDTSAESSKFS |
| S9144 | A2ASS6 | −0.203903 | 0.163212 | 2 | 1 | 1 | Class 1 | NIKERLIPPSFTKKLSETVEETEGNSFKLEG |
| S22416 | A2ASS6 | −0.192457 | 0 | 2 | 1 | 0.999998 | Class 1 | EKKGLRWVRATKTPVSDLRCKVTGLQEGNTY |
| S30939 | A2ASS6 | −0.186488 | 0 | 2 | 1 | 0.998923 | Class 1 | VKVLDSPGPCGKLTVSRVTEEKCTLAWSLPQ |
| S18535 | A2ASS6 | −0.184072 | 0 | 3 | 1 | 1 | Class 1 | NTVSLTWNPPKYDGGSEIINYVLESRLIGTE |
| T266 | A2ASS6 | −0.174257 | 0.297613 | 2 | 1 | 1 | Class 1 | KTPPRIPPKPKSRSPTPPSIAAKAQLARQQS |
| S4175 | A2ASS6 | −0.168399 | 0.396358 | 3 | 1 | 1 | Class 1 | HEEDKIDVQGGRDHLSDAQKVETVIEAEADS |
| T23981 | A2ASS6 | −0.166376 | 0 | 3 | 1 | 0.5 | Class 2 | PAVTWHKDDIPLKQTTRVNAESTENNSLLTI |
| T14268 | A2ASS6 | −0.16409 | 0.087451 | 2 | 1 | 0.99985 | Class 1 | VFTKNLANLEVSEGDTIKLVCEVSKPGAEVI |
| S1529 | A2ASS6 | −0.159512 | 0.439196 | 3 | 1 | 0.943823 | Class 1 | KEDGTQSLIIVPASPSDSGEWTVVAQNRAGK |
| S9459 | A2ASS6 | −0.158813 | 0.124587 | 3 | 1 | 1 | Class 1 | DLRAMLKKTPALKKGSGEEEEIDIMELLKNV |
| T30575 | A2ASS6 | −0.154592 | 0 | 3 | 1 | 0.788648 | Class 1 | TEITNYIVEKRESGTTAWQLINSSVKRTQIK |
| S28281 | A2ASS6 | −0.146693 | 0.305079 | 3 | 1 | 0.999999 | Class 1 | DMKNFPSHTVYVRAGSNLKVDIPISGKPLPK |
| S26695 | A2ASS6 | −0.140014 | 0.346765 | 3 | 1 | 0.797368 | Class 1 | EPVIACNPYKRPGPPSTPEASAITKDSMVLT |
| S24391 | A2ASS6 | −0.137242 | 0.088548 | 2 | 1 | 0.993652 | Class 1 | TARLEIKSTDFATSLSVKDAVRVDSGNYILK |
| T29649 | A2ASS6 | −0.134127 | 0.58377 | 3 | 1 | 0.997724 | Class 1 | PSKFTLAVSPVDPPGTPDYIDVTRETITLKW |
| T21731 | A2ASS6 | −0.127027 | 0 | 2 | 1 | 0.718367 | Class 2 | NKWQRVMKSLSLQYSTKDLKEGKEYTFRVSA |
| T33772 | A2ASS6 | −0.120166 | 0.177658 | 2 | 1 | 1 | Class 1 | RMPYEVPEPRRFKQATVEEDQRIKQFVPMSD |
| S16477 | A2ASS6 | −0.120059 | 0.290657 | 2 | 1 | 0.960016 | Class 1 | KAVDPIDAPKVILRTSLEVKRGDEIALDATI |
| T25842 | A2ASS6 | −0.117083 | 0 | 2 | 1 | 0.999999 | Class 1 | AGGSARIHIPFKGRPTPEITWSKEEGEFTDK |
| S17015 | A2ASS6 | −0.116476 | 0 | 3 | 1 | 0.999637 | Class 1 | KMCLLNWSDPADDGGSDITGFIIERKDAKMH |
| S3827 | A2ASS6-3 | −0.110284 | 0.69199 | 2 | 1 | 1 | Class 1 | SNEEVHGYKSRGICESPDKVSQVLTPYPSES |
| S34488 | A2ASS6 | −0.108085 | 0.264442 | 2 | 1 | 0.999994 | Class 1 | RVKSPEPVTSHPKAVSPTETKPTEKGQHLPV |
| S790 | A2ASS6 | −0.10482 | 0 | 3 | 1 | 0.790373 | Class 1 | ETHIKTTDQMGMHISSQVKKTTDISTERLVH |
| T26696 | A2ASS6 | −0.0857946 | 0.182593 | 3 | 1 | 0.989467 | Class 1 | PVIACNPYKRPGPPSTPEASAITKDSMVLTW |
| S1977 | A2ASS6 | −0.081692 | 0.055874 | 2 | 1 | 0.990373 | Class 1 | KLQFEVQKVDRPVDTSETKEVVKLKRAERIT |
| S19447 | A2ASS6 | −0.0663668 | 0 | 2 | 1 | 0.591546 | Class 2 | KQDTRKGTWGVVSAGSSKLKLKVPHLQKGCE |
| S13204 | A2ASS6 | −0.0662166 | 0.089154 | 2 | 1 | 0.880947 | Class 1 | LKPIEDVTIYEKESASFDAEISEEDIPGEWK |
| S25920 | A2ASS6 | −0.0488367 | 0.044418 | 3 | 1 | 1 | Class 1 | PGPPQNLAVKEVRKDSVLLVWEPPIIDGGAK |
| S22804 | A2ASS6 | −0.0380723 | 0.014722 | 2 | 1 | 0.805129 | Class 1 | VIEAQRKGSDQWTHISTVKGLECVVRNLTEG |
| S34611 | A2ASS6 | −0.0345249 | 0 | 2 | 1 | 0.68296 | Class2 | TGQSFKSIHEQVSSISETTKSVQKTAESAEA |
| S30572 | A2ASS6 | −0.0335397 | 0 | 2 | 1 | 0.832922 | Class 1 | DGGTEITNYIVEKRESGTTAWQLINSSVKRT |
| S35063 | A2ASS6 | −0.0245479 | 0 | 2 | 1 | 0.632417 | Class2 | KQEASFSSFSSSSASSMTEMKFASMSAQSMS |
| S4018 | A2ASS6 | −0.018641 | 0 | 2 | 1 | 0.675564 | Class 2 | VLLKEEQSEVVAVPTSQTSKSEKEPEAIKGV |
| S35036 | A2ASS6 | −0.0161605 | 0 | 2 | 1 | 0.952755 | Class 1 | REVVLKTSSDVSLHGSVSSQSVQMSASKQEA |
| S3991 | A2ASS6 | −0.0149712 | 0.0107483 | 2 | 1 | 0.999502 | Class 1 | KSTGQDVALRTEEGKSLSFPLALEEKQVLLK |
| S17113 | A2ASS6 | −0.01187 | 0.0154739 | 3 | 1 | 0.985972 | Class 1 | STITLDWKEPRSDGGSPIQGYIIEKRRHDKP |
| S814 | A2ASS6 | −0.0108688 | 0.0162498 | 2 | 1 | 0.999999 | Class 1 | STERLVHVDKRPRTASPHFTVSKISVPKTEH |
| S20755 | A2ASS6 | −0.0093163 | 0.0181907 | 2 | 1 | 1 | Class 1 | DGSSVLIIKDVTRKDSGYYSLTAENSSGSDT |
| S27556 | A2ASS6 | −0.0092088 | 0.0073245 | 2 | 1 | 0.999755 | Class 1 | DQRYEFRVFARNAADSVSEPSESTGPITVKD |
| S3870 | A2ASS6 | −0.0051650 | 0.0056415 | 3 | 1 | 0.991661 | Class 1 | EPEGVFPGASSAAQVSPVTIKPLITLTAEPK |
| S4672 | A2ASS6-3 | −0.0048496 | 0.0087214 | 3 | 1 | 1 | Class 1 | ENGDKTFISQLKRAASEEECLEDHEMEDGPT |
| S28731 | A2ASS6 | −0.0040724 | 0.0043022 | 2 | 1 | 0.974739 | Class 1 | LASILIKDANRLNSGSYELKLRNAMGSASAT |
| S17109 | A2ASS6 | 0.00032406 | 0 | 3 | 1 | 0.836525 | Class 1 | ERTKSTITLDWKEPRSDGGSPIQGYIIEKRR |
| S14664 | A2ASS6 | 0.0113125 | 0.0110327 | 2 | 1 | 1 | Class 1 | REIKEGKKYKFEKDGSIHRLIIKDCRLEDEC |
| T21632 | A2ASS6 | 0.0207359 | 0 | 2 | 1 | 0.819558 | Class 1 | AERKSWSTVTTECSKTSFRVSNLEEGKSYFF |
| S17316 | A2ASS6 | 0.02154 | 0 | 3 | 1 | 0.980872 | Class 1 | ESCYLTWDAPLDNGGSEITHYIIDKRDASRK |
| S34623 | A2ASS6 | 0.0307702 | 0.0977465 | 2 | 1 | 1 | Class 1 | SSISETTKSVQKTAESPEAKKQEPIAPESIS |
| S756 | A2ASS6 | 0.0341452 | 0.0943439 | 3 | 1 | 1 | Class 1 | HISTTKVPEQPRRPASEPHVVPQAVKPAVIQ |
| S34573 | A2ASS6 | 0.0437442 | 0 | 3 | 1 | 0.978092 | Class 1 | SADGTYELKIHNLSESDCGEYVCEVSGEGGT |
| S34571 | A2ASS6 | 0.120101 | 0 | 2 | 1 | 0.99376 | Class 1 | HYSADGTYELKIHNLSESDCGEYVCEVSGEG |
| T32113 | A2ASS6 | 0.130455 | 0 | 3 | 1 | 0.999962 | Class 1 | GISKPLKSEEPVIPKTPLNPPEPPSNPPEVL |
| T25315 | A2ASS6 | 0.134102 | 0 | 3 | 1 | 1 | Class 1 | NSECYVARDPCDPPGTPEAIIVKRNEITLQW |
| S2078 | A2ASS6 | 0.155502 | 0.903734 | 2 | 1 | 1 | Class 1 | GKITIPTFKPERIELSPSMEAPKIFERIQSQ |
| T21345 | A2ASS6 | 0.156475 | 0.125556 | 3 | 1 | 0.999996 | Class 1 | PVIERTLKATGLQEGTEYEFRVTAINKAGPG |
| S31438 | A2ASS6 | 0.158509 | 0 | 2 | 1 | 0.78457 | Class 1 | VPLVPTKLEVVDVTKSTVTLAWEKPLYDGGS |
| S34488 | A2ASS6 | 0.158631 | 0 | 2 | 2 | 0.999994 | Class 1 | RVKSPEPVTSHPKAVSPTETKPTEKGQHLPV |
| S34476 | A2ASS6 | 0.159999 | 0 | 2 | 2 | 1 | Class 1 | RVKSPETVKSPKRVKSPEPVTSHPKAVSPTE |
| S35128 | A2ASS6 | 0.165174 | 0.213397 | 2 | 1 | 0.999984 | Class 1 | GRGIPPKIEALPSDISIDEGKVLTVACAFTG |
| S315 | A2ASS6 | 0.166903 | 0.183848 | 2 | 2 | 0.997856 | Class 1 | PSPVRSVSPAGRISTSPIRSVKSPLLIRKTQ |
| S22797 | A2ASS6 | 0.170233 | 0.274145 | 2 | 1 | 1 | Class 1 | GSKITGYVIEAQRKGSDQWTHISTVKGLECV |
| S25870 | A2ASS6 | 0.199285 | 0 | 2 | 1 | 1 | Class 1 | TDKVQIEKGINFTQLSIDNCDRNDAGKYILK |
| S13764 | A2ASS6 | 0.200173 | 0 | 2 | 1 | 1 | Class 1 | SWFKNDQRLHTSKRVSMHDEGKTHSITFKDL |
| S814 | A2ASS6 | 0.200474 | 0.566341 | 2 | 2 | 0.999999 | Class 1 | STERLVHVDKRPRTASPHFTVSKISVPKTEH |
| S21152 | A2ASS6 | 0.207222 | 0.196717 | 2 | 1 | 1 | Class 1 | RNLCTLELFSVNRKDSGDYTITAENSSGSKS |
| S307 | A2ASS6 | 0.21303 | 0.565178 | 2 | 1 | 1 | Class 1 | VRHVRAPTPSPVRSVSPAGRISTSPIRSVKS |
| S2078 | A2ASS6 | 0.216232 | 0.446394 | 2 | 2 | 1 | Class 1 | GKITIPTFKPERIELSPSMEAPKIFERIQSQ |
| S2080 | A2ASS6 | 0.216232 | 0.446394 | 2 | 2 | 1 | Class 1 | ITIPTFKPERIELSPSMEAPKIFERIQSQTV |
| S33353 | A2ASS6 | 0.219718 | 0.237812 | 3 | 1 | 1 | Class 1 | IRSQRGVSVAKVKVASIEIGPVSGQIMHAIG |
| T812 | A2ASS6 | 0.223205 | 0.643762 | 4 | 2 | 0.999999 | Class 1 | DISTERLVHVDKRPRTASPHFTVSKISVPKT |
| Y33436 | A2ASS6 | 0.229236 | 0 | 2 | 1 | 0.996224 | Class 1 | TKFDDGTYRCKVVNDYGEDSSYAELFVKGVR |
| S264 | A2ASS6 | 0.246749 | 0.784633 | 2 | 1 | 1 | Class 1 | PHKTPPRIPPKPKSRSPTPPSIAAKAQLARQ |
| S3676 | A2ASS6 | 0.258327 | 0 | 4 | 1 | 0.878152 | Class 1 | EDMPLYTSVCYTIIHSPDGSGTFIVNDPQRG |
| S879 | A2ASS6 | 0.26138 | 0.407205 | 3 | 1 | 0.998042 | Class 1 | TVKPGETRVRAEPTPSPQFPFADMPPPDTYK |
| S1214 | A2ASS6 | 0.287447 | 0.235319 | 2 | 1 | 1 | Class 1 | IQEPKVGEIAPGFAYSEYEKEYEKEQALIRK |
| S322 | A2ASS6 | 0.325277 | 3.06343 | 2 | 1 | 1 | Class 1 | SPAGRISTSPIRSVKSPLLIRKTQTTTMATG |
| S12678 | A2ASS6 | 0.331543 | 0.65471 | 3 | 1 | 1 | Class 1 | IEKPKLKPRPPARPPSPPKEDVKEKMFQLKA |
| T266 | A2ASS6 | 0.332311 | 0.771702 | 2 | 2 | 1 | Class 1 | KTPPRIPPKPKSRSPTPPSIAAKAQLARQQS |
| S2032 | A2ASS6 | 0.353204 | 0.75905 | 2 | 1 | 1 | Class 1 | EAITAVELKSRKKDESYEELLKKTKDELLHW |
A-band.