Table 4.
Estimated bacterial concentration per VMB type and by proportion of pathobionts (Rwanda VMB study only, multiple samples per woman).
| VMB type | Estimated total bacterial concentration in log10 cells/μl | |||
|---|---|---|---|---|
| N |
All samples Mean (95% CI)b |
N |
Not influenced by interventionsa Mean (95% CI)c |
|
| Lactobacillus iners-dominated (Li) | 144 | 5.81 (5.69–5.92) | 34 | 5.99 (5.75–6.22) |
| L. crispatus-dominated (Lcr) | 9 | 5.36 (4.99–5.72) | 3 | 5.43 (4.51–6.35) |
| Other lactobacilli-dominated (Lo) | 10 | 5.13 (4.63–5.64) | 3 | 5.59 (4.13–7.05) |
| Lactobacilli and BV-anaerobes (LA) | 57 | 6.31 (6.11–6.51) | 21 | 6.34 (5.96–6.73) |
| Polybacterial Gardnerella vaginalis-containing (BV_GV) | 90 | 6.87 (6.72–7.02) | 57 | 6.91 (6.72–7.11) |
| Polybacterial but low G. vaginalis (BV_noGV) | 16 | 6.29 (5.75–6.82) | 14 | 6.15 (5.57–6.73) |
| G. vaginalis-dominated (GV) | 27 | 6.11 (5.77–6.46) | 16 | 6.14 (5.64–6.64) |
| Pathobionts-containing (PB) | 26 | 5.85 (5.43–6.27) | 10 | 5.76 (4.76–6.76) |
| Proportion pathobionts | Estimated total bacterial concentration in log10 cells/μl | |||
| <1% | 289 | 6.17 (6.07–6.27) | 124 | 6.47 (6.31–6.62) |
| 1%–<10% | 50 | 6.14 (5.89–6.38) | 19 | 6.05 (5.69–6.42) |
| 10%–<20% | 14 | 6.33 (5.89–6.78) | 5 | 6.29 (5.02–7.56) |
| 20%–<50% | 15 | 6.04 (5.49–6.59) | 8 | 6.18 (5.22–7.15) |
| ≥50% | 11 | 5.59 (4.84–6.34) | 2 | 4.06 (−5.20–13.33) |
| Proportion pathobionts | Estimated pathobionts concentration in log10 cells/μl | |||
| <1% | 289 | 1.36 (1.16–11.56) | 124 | 1.32 (0.99–1.65) |
| 1%–<10% | 50 | 4.38 (4.12–4.63) | 19 | 4.21 (3.84–4.58) |
| 10%–<20% | 14 | 5.25 (4.80–5.69) | 5 | 5.21 (4.00–6.41) |
| 20%–<50% | 15 | 5.40 (4.85–5.94) | 8 | 5.51 (4.51–6.50) |
| ≥50% | 11 | 5.41 (4.71–6.12) | 2 | 4.00 (−6.02–14.02) |
BV, bacterial vaginosis; CI, confidence interval; VMB, vaginal microbiota.
Estimated concentrations were only available for the Rwanda VMB study. Samples collected at the screening and Month 6 visits in all randomization groups, and at the Month 1 and Month 2 visits in the no-intervention group, were considered not influenced by the interventions.
The Kruskall Wallis p-values comparing the relevant categories are <0.001 for VMB types and estimated total bacterial concentration, 0.606 for pathobionts proportion and estimated total bacterial concentration, and <0.001 for pathobionts proportion and estimated pathobionts concentration.
The Kruskall Wallis p-value comparing the relevant categories are <0.001 for VMB types, 0.061 for pathobionts proportion and estimated total bacterial concentration, and <0.001 for pathobionts proportion and estimated pathobionts concentration.