TABLE 2.
All potential mutations identified with altered amino acid sequence
| Gene | Mutation | Fitness scorea | Antibiotic |
|---|---|---|---|
| soxR | G121K | 14.21059826 | Doxycycline |
| soxR | I120E | 13.41328904 | Doxycycline |
| soxR | G121N | 12.61816091 | Doxycycline |
| soxR | G121P | 10.68028162 | Doxycycline |
| soxR | G121I | 9.176806682 | Doxycycline |
| soxR | I120D | 2.9096309542 | Doxycycline |
| soxR | I120E | 1.3365831269 | Thiamphenicol |
| crp | V140W | 11.1088135691 | Gentamicin |
a
The fitness score (or enrichment score) was used to evaluate the fitness contribution of each mutation under the various selection pressures investigated (23).