FIGURE 5.

Promoter-based DMR enrichment of known response elements. (A) Known motif enrichment of hyper-methylated DMRs localized to the promoter region based on the ENCODE database of ChIP-sequencing datasets. (B) Downstream ELK4 targets genes with hyper-methylated (Q < 0.05, | methylation| > 5%) promoters based on the ENCODE ChIP-sequencing dataset by Cayting et al. (GSE31477). (C) Gene-set enrichment analysis of ELK4 gene targets with hyper-methylated promoters, showing the top-5 disproportionately enriched pathways.