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How alteration of functional BDNF result in depression. In brief, BDNF is a molecule involved in the control of synapse formation and regulation of activity-dependent changes in synapse structure and function. BDNF stimulation increases synaptic spine density by a mechanism dependent on the Ras/ERK pathway. Dysfunction or decreased BDNF leads to malfunction of synaptic plasticity, and decreased excitatory neurons and glutamate; and eventually lead to depression.
