Table 2.
Immuno-Oncology (IO) targets of curcumin identified by TCMIO.
| Target Name | ChEMBL ID | Type | Activity (nM) |
|---|---|---|---|
| Epidermal growth factor receptor | CHEMBL203 | Known | IC50 = 8650 |
| Hypoxia-inducible factor 1-alpha | CHEMBL426 | Known | Potency=6309.6 |
| Mitogen-activated protein kinase 1 | CHEMBL4040 | Known | Potency=31622.8 |
| Thyrotropin receptor | CHEMBL1963 | Known | Potency=10000 |
| Toll-like receptor 9 | CHEMBL5804 | Known | IC50 = 8362 |
| Nuclear factor erythroid 2-related factor 2 | CHEMBL1075094 | Predicted | N/A |
| Prostaglandin G/H synthase 2 | CHEMBL230 | Predicted | N/A |
| Signal transducer and activator of transcription 3 | CHEMBL4026 | Predicted | N/A |