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. 2020 Apr 15;11:314. doi: 10.3389/fphys.2020.00314

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Copyright © 2020 Bartolucci, Passini, Hyttinen, Paci and Severi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Repolarization abnormalities – EADs. (A) Examples of different responses to dofetilide (0.1 μM), CL = 4,000 ms (Guo et al., 2011). Top: repolarizing models (black, REP); middle: models developing early afterdepolarizations (magenta, EAD) and bottom panel failing to repolarize (cyan, RF). (B) Distribution of the scaling factors which show statistically significant differences between the three categories: models repolarizing (REP, black), models developing EADs (EAD, magenta) and models failing to repolarize (RF, cyan) (*p < 0.05). Red crosses represent outliers. (C) EAD induced by I_CaL reactivation (left) and EAD induced by Ca²⁺ release from SR (right).