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. 2020 Apr 15;11:314. doi: 10.3389/fphys.2020.00314

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Copyright © 2020 Bartolucci, Passini, Hyttinen, Paci and Severi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ca²⁺-dependence inactivation. Left: framework for isolating the Ca²⁺-dependent inactivation (CDI) (from Limpitikul et al., 2018). Top: voltage step. Middle: [Ca²⁺]_ss example of concentration step. Bottom: I_CaL current in response to voltage activation at baseline [Ca²⁺]_ss (black) and in response to a [Ca²⁺]_ss step (magenta). Right: Steady state CDI (evaluated as a/b) as a function of [Ca²⁺]_ss with ORd (light blue) and BPS2020 model (dark blue), fitted with a Boltzmann curve; CDI quantification are also highlighted for different [Ca²⁺]_o values (magenta for BPS2020 and purple for ORd).