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. 2020 Apr 15;11:295. doi: 10.3389/fpsyt.2020.00295

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Copyright © 2020 Zhang, Geng, Li, Li, Xu, Wu, Xie, Sun, Wei and Qiao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Results of the effect of paeonol on the premenstrual dysphoric disorder-progesterone withdrawal (PMDD-PWD) rat model in the elevated plus maze (EPM) test. (A) Total distance in the EPM test. (B) Distance in the closed arm in the EPM test. (C) Closed arm entry times in the EPM test. (D) Total entry times in the EPM test. (E) Percentage of time in the open arm in the EPM test. (F) Percentage of open-arm entry times in the EPM test. PMDD-PWD, premenstrual dysphoric disorder-progesterone withdrawal; EPM, elevated plus maze; Flx, fluoxetine; Pae, paeonol; *p < 0.05 compared with the control group; **p < 0.01 compared with the control group; ^#p < 0.05 compared with the PMDD-PWD group; ^##p < 0.01 compared with the PMDD-PWD group. Twelve animals were used in each group.