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. 2020 Apr 15;11:295. doi: 10.3389/fpsyt.2020.00295

Figure 9.

Figure 9

Results of the effect of paeonol on the resident intruder model of premenstrual dysphoric disorder (PMDD) in the open-field test (OFT) and elevated plus maze (EPM) and composite aggressive tests. (A) Total distance in the OFT. (B) Distance in the central area in the OFT. (C) Time in the central area in the OFT. (D) Total distance in the EPM test. (E) Percentage of time in the open arm in the EPM test. (F) Percentage of open-arm entry times in the EPM test. (G) Composite aggressive score before the drug administration. (H) Composite aggressive score after the drug administration. PMDD-RIP, premenstrual dysphoric disorder-resident intruder paradigm; OFT, open-field test; EPM, elevated plus maze; Flx, fluoxetine; Pae, paeonol; *p < 0.05 compared with the control group; ***p < 0.001 compared with control group; #p < 0.05 compared with the PMDD-RIP group; ##p < 0.01 compared with the PMDD-RIP group; ###p < 0.001 compared with the PMDD-RIP group; ####p < 0.0001 compared with the PMDD-RIP group. Twelve animals were used in each group.